Lawrence C, Fabry M E, Nagel R L
J Lab Clin Med. 1985 Jun;105(6):706-10.
We reported previously that painful crises in patients with sickle cell anemia are accompanied by striking decreases in the percent of densest red cells (fraction 4) when studied with isopyknic Percoll-Stractan gradients. We report that an alternative to density gradients is the red cell distribution width (RDW), an estimate of red cell size variation measured with a Coulter counter. In 17 painful crises in 12 patients with homozygous sickle cell anemia the RDWs decreased in each crisis, from an initial mean of 16.2 +/- 1.8 SD to 12.8 +/- 1.3 (P less than 0.001). In patients in whom serial measurements of both RDW and fraction 4 (very dense) red cells were taken during crisis, the two measurements declined in parallel. The decrease of RDW is a readily observable and objective laboratory concomitant of painful sickle crisis.
我们之前报道过，当使用等密度Percoll-Stractan梯度进行研究时，镰状细胞贫血患者的疼痛性危象伴随着最致密红细胞百分比（第4部分）的显著下降。我们报告，密度梯度的一种替代方法是红细胞分布宽度（RDW），它是用库尔特计数器测量的红细胞大小变异的估计值。在12例纯合镰状细胞贫血患者的17次疼痛性危象中，每次危象时RDW均下降，从初始平均值16.2±1.8标准差降至12.8±1.3（P<0.001）。在危象期间对RDW和第4部分（非常致密）红细胞进行连续测量的患者中，这两项测量结果平行下降。RDW的降低是疼痛性镰状危象易于观察到的客观实验室伴随现象。
