Gau Shuo-Yan, Chen Chih-Wei, Wang Yu-Hsun, Chi Ching-Chi, Wei James Cheng-Chung
School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Education, Chang Gung Memorial Hospital, Kaohsiung Branch, Kaohsiung, Taiwan; Department and Graduate Institute of Business Administration, College of Management, National Taiwan University, Taipei, Taiwan.
Data Finance Innovation Research Center, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; National Council for Sustainable Development, Executive Yuan, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Faculty of Engineering Sciences, University College London, London, UK.
Biomed J. 2025 Feb 20;48(3):100837. doi: 10.1016/j.bj.2025.100837.
Hidradenitis suppurativa (HS) and alopecia areata (AA) share similar inflammatory pathway and pro-inflammatory cytokines. However, the association between HS and AA was unclear. We aimed to evaluate the risk of incident AA among patients with HS.
We performed a multicenter cohort study using the US Collaborative Network in the TriNetX Research Network. Patients with HS diagnosis were recruited and 1:1 propensity score matching was performed to identify the non-HS control group. Hazard ratio (HR) of AA in different sensitivity models were calculated within the follow-up periods.
Comparing with non-HS controls, the risk of incident AA in HS patients was 1.79-fold higher (95% confidence interval (CI) 1.31-2.44) within 15-year follow up. Similar trends were observed in 3-year and 8-year follow up. For female HS patients, the risk of incident AA was 1.75-fold higher than non-HS female (95% CI 1.23-2.48). However, the trend was not observed in male HS patients (HR 1.52; 95% CI 0.79-2.94).
Patients with HS were associated with increased risk of incident AA. Clinicians should be aware of the observed association and the actual immunological interplay between the two diseases should be clarified in future lab-based studies.
化脓性汗腺炎（HS）和斑秃（AA）具有相似的炎症途径和促炎细胞因子。然而，HS与AA之间的关联尚不清楚。我们旨在评估HS患者发生AA的风险。
我们利用TriNetX研究网络中的美国协作网络进行了一项多中心队列研究。招募了诊断为HS的患者，并进行1:1倾向评分匹配以确定非HS对照组。在随访期内计算不同敏感性模型中AA的风险比（HR）。
与非HS对照组相比，HS患者在15年随访期内发生AA的风险高1.79倍（95%置信区间（CI）1.31 - 2.44）。在3年和8年随访中观察到类似趋势。对于女性HS患者，发生AA的风险比非HS女性高1.75倍（95% CI 1.23 - 2.48）。然而，在男性HS患者中未观察到该趋势（HR 1.52；95% CI 0.79 - 2.94）。
HS患者发生AA的风险增加。临床医生应意识到所观察到的关联，并且两种疾病之间实际的免疫相互作用应在未来基于实验室的研究中阐明。
