Jia Hai-Yuan, Xu Tao, Wang Chen, Zhu Hong-Wei, Li Bing-Zhi, Yuan Ying-Jin, Liu Zhi-Hua
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology, Tianjin 300072, China; Frontiers Research Institute for Synthetic Biology, Tianjin University 301799, China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology, Tianjin 300072, China; Frontiers Research Institute for Synthetic Biology, Tianjin University 301799, China.
Bioresour Technol. 2025 May;424:132278. doi: 10.1016/j.biortech.2025.132278. Epub 2025 Feb 20.
Lignin is the largest renewable aromatic resource available for producing high-value products such as biomaterials, biofuels, and chemicals. Polyhydroxyalkanoate (PHA) is a biodegradable and biocompatible polymer synthesized by various microorganisms, offering broad application potential. Microbial conversion of lignin-derived aromatics into PHA promoted both lignin valorization and PHA biosynthesis. However, lignin's recalcitrance and heterogeneity pose significant challenges for its microbial degradation and value-added utilization. This review examines the entire pathway of lignin conversion into high-value products, highlighting the advantages of microbial processes for synthesizing PHA and promoting the biological upgrading of lignin. Additionally, synthetic biology techniques and metabolic regulation strategies can further enhance microbial PHA synthesis. Overall, integrating microbial PHA synthesis with lignin bioconversion not only facilitates lignin valorization but also supports the sustainable production of PHA, making a significant contribution to the utilization and sustainable development of biomass resources.
木质素是可用于生产生物材料、生物燃料和化学品等高价值产品的最大可再生芳香族资源。聚羟基脂肪酸酯（PHA）是一种由多种微生物合成的可生物降解且具有生物相容性的聚合物，具有广泛的应用潜力。将木质素衍生的芳烃微生物转化为PHA既促进了木质素的增值利用，又促进了PHA的生物合成。然而，木质素的顽固性和异质性对其微生物降解和增值利用提出了重大挑战。本文综述了木质素转化为高价值产品的整个途径，强调了微生物合成PHA和促进木质素生物升级的优势。此外，合成生物学技术和代谢调控策略可以进一步提高微生物PHA的合成。总体而言，将微生物PHA合成与木质素生物转化相结合不仅有助于木质素的增值利用，还支持PHA的可持续生产，为生物质资源的利用和可持续发展做出了重大贡献。
