Zheng Jiawen, Manabe Yuki, Sugawara Tatsuya
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University. Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University. Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Apr;1870(3):159604. doi: 10.1016/j.bbalip.2025.159604. Epub 2025 Feb 20.
Diabetic nephropathy is a complication of diabetes mellitus characterized by the gradual progression of renal insufficiency, resulting in renal failure. Approximately 15 % or more of patients with type 2 diabetes mellitus have diabetic nephropathy. Siphonaxanthin is a green algal carotenoid noted for its strong biological activities, including anti-obesity effects. In this study, we aimed to evaluate the preventive effects of siphonaxanthin on diabetic nephropathy using db/db mice as a type 2 diabetes mellitus and diabetic nephropathy model. Ingestion of AIN-93G containing 0.004 % w/w siphonaxanthin did not improve plasma creatinine and urine albumin levels but significantly mitigated renal morphological changes in diabetic mice. Moreover, siphonaxanthin restored the decreased mRNA expression of fatty acid β-oxidation-related proteins in the skeletal muscle. These results indicate that siphonaxanthin can potentially ameliorate type 2 diabetes mellitus-induced kidney damage and lipid metabolism insufficiency in skeletal muscle. This study provides a possible daily nutraceutical solution for treating diabetic nephropathy and lipid metabolic abnormalities.
糖尿病肾病是糖尿病的一种并发症，其特征为肾功能不全逐渐进展，最终导致肾衰竭。约15%或更多的2型糖尿病患者患有糖尿病肾病。虹吸藻黄素是一种绿藻类胡萝卜素，以其强大的生物活性（包括抗肥胖作用）而闻名。在本研究中，我们旨在以db/db小鼠作为2型糖尿病和糖尿病肾病模型，评估虹吸藻黄素对糖尿病肾病的预防作用。摄入含有0.004%（w/w）虹吸藻黄素的AIN-93G并未改善血浆肌酐和尿白蛋白水平，但显著减轻了糖尿病小鼠的肾脏形态学变化。此外，虹吸藻黄素恢复了骨骼肌中脂肪酸β-氧化相关蛋白降低的mRNA表达。这些结果表明，虹吸藻黄素可能改善2型糖尿病诱导的肾脏损伤和骨骼肌脂质代谢不足。本研究为治疗糖尿病肾病和脂质代谢异常提供了一种可能的日常营养补充剂解决方案。
