从大鼠蓝斑和面神经核分离出的单个神经细胞中的胆碱酯酶：一项微量气体测定研究。

Cholinesterases in single nerve cells isolated from the locus ceruleus and from nucleus of the facial nerve of the rat: a microgasometric study.

作者信息

Sket D, Pavlin R

出版信息

J Neurochem. 1985 Jul;45(1):319-23. doi: 10.1111/j.1471-4159.1985.tb05509.x.

DOI:10.1111/j.1471-4159.1985.tb05509.x

Abstract

Cholinesterase activity in single nerve cell bodies isolated from the locus ceruleus and nucleus of the facial nerve of the rat was analyzed by the microgasometric method. Acetylcholinesterase activity is about the same in both types of cells. Nonspecific cholinesterase is present in noradrenergic cells of the locus ceruleus but not in the cholinergic cells of the nucleus of the facial nerve. The total activity of cholinesterases and the activity of acetylcholinesterase in nerve cell bodies isolated from the locus ceruleus remains practically unchanged from the tenth postnatal day until the age of 24 months. Depletion of noradrenaline by a high dose of reserpine does not influence the total activity of cholinesterases in nerve cell bodies of locus ceruleus.

摘要

采用微量气体分析法对从大鼠蓝斑和面神经核分离出的单个神经细胞体中的胆碱酯酶活性进行了分析。两种类型的细胞中乙酰胆碱酯酶活性大致相同。非特异性胆碱酯酶存在于蓝斑的去甲肾上腺素能细胞中，但不存在于面神经核的胆碱能细胞中。从出生后第十天到24个月龄，从蓝斑分离出的神经细胞体中胆碱酯酶的总活性和乙酰胆碱酯酶的活性实际上保持不变。高剂量利血平耗竭去甲肾上腺素并不影响蓝斑神经细胞体中胆碱酯酶的总活性。