Ma Yaohui, Gong Hang, Cheng Long, Zhang Dekui
Department of Gastroenterology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, People's Republic of China.
Int J Gen Med. 2025 Feb 19;18:907-926. doi: 10.2147/IJGM.S487093. eCollection 2025.
Macrophages, as a crucial component of the body's immune system, play a vital role in the onset, progression, and outcome of diseases. Discoidin domain receptors (DDRs), important members of the novel receptor tyrosine kinase superfamily, exhibit unique functions in macrophage physiology. Through interactions with the extracellular matrix, DDRs activate signaling pathways such as p38 MAPK and NF-κB, regulating macrophage adhesion, migration, and secretory functions, thereby influencing their behavior in diseases. Recent studies have indicated a direct correlation between DDRs and the progression of various diseases, including inflammation, cancer, and fibrosis. However, there remain numerous knowledge gaps regarding the specific mechanisms by which DDRs function in macrophage-mediated diseases. This article provides an in-depth summary of the regulatory mechanisms of DDRs on macrophages, detailing their modulatory roles in various diseases through macrophages and their underlying mechanisms. The aim is to offer new insights into biomedical therapies targeting DDRs and the development of novel drugs.
巨噬细胞作为人体免疫系统的关键组成部分，在疾病的发生、发展和转归中起着至关重要的作用。盘状结构域受体（DDRs）是新型受体酪氨酸激酶超家族的重要成员，在巨噬细胞生理过程中发挥着独特的功能。通过与细胞外基质相互作用，DDRs激活p38丝裂原活化蛋白激酶（p38 MAPK）和核因子κB（NF-κB）等信号通路，调节巨噬细胞的黏附、迁移和分泌功能，从而影响它们在疾病中的行为。最近的研究表明，DDRs与包括炎症、癌症和纤维化在内的各种疾病的进展直接相关。然而，关于DDRs在巨噬细胞介导的疾病中发挥作用的具体机制，仍存在许多知识空白。本文深入总结了DDRs对巨噬细胞的调控机制，详细阐述了它们通过巨噬细胞在各种疾病中的调节作用及其潜在机制。目的是为针对DDRs的生物医学治疗和新型药物的开发提供新的见解。
