Song Yun Je, Lim Jun Kyeong, Choi Jun-Ho
Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea.
Korean J Intern Med. 2025 Mar;40(2):170-180. doi: 10.3904/kjim.2024.293. Epub 2025 Feb 25.
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishing PNETs from other tumors, while EUS-guided fine-needle aspiration or biopsy has improved the histological diagnosis and grading of tumors. The recent introduction of EUS-guided ablation using ethanol injection or radiofrequency ablation has offered an alternative to surgery in the management of PNETs. Comparisons with surgery have shown similar outcomes but fewer adverse effects. Although standardized protocols and prospective studies with long-term follow-up are still needed, EUS-based methods are promising approaches that can contribute to a better quality of life for PNET patients.
诊断技术的进步使得胰腺神经内分泌肿瘤（PNETs）的检测得到改善，从而导致报告病例数增加。内镜超声（EUS）技术，包括与对比增强谐波成像相结合，有助于将PNETs与其他肿瘤区分开来，而EUS引导下的细针穿刺抽吸或活检改善了肿瘤的组织学诊断和分级。最近采用乙醇注射或射频消融的EUS引导下消融术为PNETs的治疗提供了一种替代手术的方法。与手术的比较显示出相似的结果，但不良反应较少。尽管仍需要标准化方案和长期随访的前瞻性研究，但基于EUS的方法是有前景的途径，可为PNET患者带来更好的生活质量。
