Ter-Ovanesyan Irina, Tashjian Michelle, Escruceria Stephanie, Fernandez Richard, Estadella Bryant, Mayrovitz Harvey N
Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.
Cureus. 2025 Jan 25;17(1):e77981. doi: 10.7759/cureus.77981. eCollection 2025 Jan.
The lymphatic system is essential in maintaining skin health through coordinated immunological actions. This review explores the relationship between lymphatic function and skin health, as well as the impact of lymphatic dysfunction in the development and progression of inflammatory skin disorders. A systemic search was conducted in the Web of Science, Embase, and Ovid MEDLINE databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. Included studies were peer-reviewed human or animal research published in English from 2014 to 2024, focusing on inflammatory skin disorders, including skin cancer, autoimmune skin diseases, and infectious skin diseases. A total of 1232 citations were identified, with 37 studies meeting the eligibility criteria after assessment and critical appraisal. The review's findings highlight the essential role of lymphatics in maintaining skin health, mitigating inflammatory, infectious, and skin cancer-related processes, and delaying the effects of skin aging. The mechanisms underlying lymphatic function in these processes are complex, with some aspects needing further investigation. However, the evidence indicates that a well-functioning skin lymphatic system, supported by various cytokines, aids in reducing the inflammatory state, reduces inflammation, alleviates lymphedema, and prevents lymphatic stasis, which can increase infection risk. Several studies demonstrated that restoring lymphatic function through improved neutrophil migration and cytokine responses reduces the spread of infectious diseases.
淋巴系统通过协调免疫作用对维持皮肤健康至关重要。本综述探讨了淋巴功能与皮肤健康之间的关系，以及淋巴功能障碍在炎症性皮肤病发生和发展中的影响。按照系统评价和范围综述的系统评价与Meta分析扩展版（PRISMA-ScR）指南，在科学网、Embase和Ovid MEDLINE数据库中进行了全面检索。纳入的研究为2014年至2024年以英文发表的经同行评审的人类或动物研究，重点关注炎症性皮肤病，包括皮肤癌、自身免疫性皮肤病和感染性皮肤病。共识别出1232条引文，经评估和严格评价后有37项研究符合纳入标准。该综述的结果强调了淋巴管在维持皮肤健康、减轻炎症、感染及皮肤癌相关过程以及延缓皮肤衰老影响方面的重要作用。这些过程中淋巴功能的潜在机制很复杂，有些方面需要进一步研究。然而，证据表明，在多种细胞因子的支持下，功能良好的皮肤淋巴系统有助于减轻炎症状态、减轻炎症、缓解淋巴水肿并防止淋巴淤滞，而淋巴淤滞会增加感染风险。多项研究表明，通过改善中性粒细胞迁移和细胞因子反应来恢复淋巴功能可减少传染病的传播。
