Borghi L, Elia G F, Trapassi M R, Barbarese F, Simoni I, Montanari A, Novarini A
Klin Wochenschr. 1985;63 Suppl 3:132-5.
The question whether body electrolyte composition in patients with primary hypertension differs from that of normotensive subjects is still controversial. The aim of the present work was to investigate on water, electrolyte, and nitrogen muscle cell composition in essential human hypertension. Also the effects of antihypertensive drugs on muscle electrolyte contents were analyzed. The results indicate that muscle Na was higher and muscle K was lower in essential hypertensives in comparison with controls. Muscle water, Mg, and nitrogen were not different in treated patients (with or without diuretics) in comparison with untreated hypertensive patients. But in hypertensive patients treated with diuretics, Nam was higher and Km was lower than in untreated patients. Several mechanisms may explain the changes on muscle electrolyte composition in primary hypertension, but the cellular mechanism involving abnormalities in ion pump and electrolyte transmembrane fluxes are the most probable. The therapy with antihypertensive drugs especially diuretics, seems to enhance different muscle electrolyte patterns in essential hypertension.
原发性高血压患者的身体电解质组成是否与血压正常者不同，这一问题仍存在争议。本研究的目的是调查原发性人类高血压患者的水、电解质和氮的肌肉细胞组成。同时还分析了抗高血压药物对肌肉电解质含量的影响。结果表明，与对照组相比，原发性高血压患者的肌肉钠含量较高，而肌肉钾含量较低。与未治疗的高血压患者相比，接受治疗的患者（使用或未使用利尿剂）的肌肉水、镁和氮含量没有差异。但在使用利尿剂治疗的高血压患者中，钠含量高于未治疗患者，钾含量低于未治疗患者。有几种机制可以解释原发性高血压患者肌肉电解质组成的变化，但涉及离子泵和电解质跨膜通量异常的细胞机制最有可能。抗高血压药物尤其是利尿剂的治疗，似乎会使原发性高血压患者出现不同的肌肉电解质模式。
