Dørup I, Skajaa K, Thybo N K
Aarhus Universitet, Fysiologisk Institut.
Ugeskr Laeger. 1994 Jul 4;156(27):4007-10, 4013.
In 76 consecutive patients who had received diuretics for 1-17 years for arterial hypertension or congestive heart failure, muscle concentrations of magnesium, potassium, and sodium-potassium pumps were significantly reduced compared to 31 age- and sex-matched controls. Thirty-six patients with muscle magnesium and/or potassium below the control level received oral magnesium hydroxide supplement for 2-12 weeks (N = 20) or 26 weeks (N = 16). After short term (2-12 weeks) magnesium supplementation muscle parameters were increased, but far from normalized. After magnesium supplementation for 26 weeks, the muscle concentrations of magnesium, potassium and sodium-potassium pumps were normalized in most cases. Oral magnesium supplementation may restore diuretic-induced disturbances in the concentrations of magnesium, potassium and sodium-potassium pumps in skeletal muscle. A supplemental period of at least six months seems required before complete normalization can be expected.
在76例因动脉高血压或充血性心力衰竭接受利尿剂治疗1至17年的连续患者中，与31例年龄和性别匹配的对照组相比，肌肉中的镁、钾和钠钾泵浓度显著降低。36例肌肉镁和/或钾低于对照水平的患者接受了2至12周（N = 20）或26周（N = 16）的口服氢氧化镁补充剂治疗。短期（2至12周）补充镁后，肌肉参数有所增加，但远未恢复正常。补充镁26周后，大多数情况下肌肉中的镁、钾和钠钾泵浓度恢复正常。口服补充镁可能会恢复利尿剂引起的骨骼肌中镁、钾和钠钾泵浓度的紊乱。在有望完全恢复正常之前，似乎需要至少六个月的补充期。
