Niimi H, Sugihara M
J Biomech Eng. 1985 May;107(2):91-5. doi: 10.1115/1.3138541.
The fluid force acting on single human red cells in a high shear flow was analyzed. A two-dimensional elliptical microcapsule as a model of the deformed red cells was adopted to numerically calculate the distributions of the shear forces on both sides of the cell membrane. It is theoretically shown that the cell membrane undergoes an unsteady cyclic loading under the rotational motion around the interior. The mechanism leading to blood cell trauma is examined by repeatedly loading the continuously moving cell membrane.
分析了高剪切流中作用于单个人类红细胞的流体力。采用二维椭圆形微胶囊作为变形红细胞的模型，对细胞膜两侧的剪切力分布进行了数值计算。从理论上表明，细胞膜在围绕内部的旋转运动下经历不稳定的循环加载。通过对连续移动的细胞膜反复加载来研究导致血细胞损伤的机制。
