早期非小细胞肺癌精准免疫治疗路线图
A Roadmap to Precision Immunotherapy for Early-Stage Non-Small Cell Lung Cancer.
作者信息
Vaccaro Alessandra, Rahal Zahraa, Kadara Humam, Cascone Tina
机构信息
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Cancer Discov. 2025 May 2;15(5):884-889. doi: 10.1158/2159-8290.CD-25-0262.
Immunotherapy has revolutionized the treatment of early-stage non-small cell lung cancer; yet many patients fail to achieve long-lasting benefit, partially because of incomplete or inconsistent biomarker predictions. Integrative multiomics, combining tumor-intrinsic, immune microenvironment, and systemic factors, offer a more comprehensive framework for precision immunotherapy, enabling improved patient stratification, treatment selection and outcomes.
免疫疗法彻底改变了早期非小细胞肺癌的治疗方式；然而，许多患者未能获得持久益处，部分原因是生物标志物预测不完整或不一致。整合多组学，结合肿瘤内在因素、免疫微环境和全身因素，为精准免疫疗法提供了一个更全面的框架，有助于改善患者分层、治疗选择和治疗效果。
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