Roberts L A, Beyer C, Komisaruk B R
Life Sci. 1985 May 27;36(21):2017-23. doi: 10.1016/0024-3205(85)90451-5.
Vaginal-cervical mechanostimulation (VS) suppresses vocalization and withdrawal responses to noxious stimulation. To determine whether the inhibitory neurotransmitter, glycine, contributes to the action of VS, strychnine, a specific glycine receptor antagonist was administered perispinally via intrathecal catheter in dosages of 1,5,25 and 100 micrograms. Prior to strychnine administration, VS (400 g force) elevated thresholds to elicit vocalization in response to graded intensities of tail shock, and blocked vocalization elicited by stimulation of a skin area, previously sensitized by intradermal injection of a 20% yeast solution. After strychnine administration the analgesic effects of VS were significantly attenuated. These findings suggest that the analgesic action of VS is partially mediated by glycine at the spinal level.
阴道-宫颈机械刺激（VS）可抑制对有害刺激的发声和退缩反应。为了确定抑制性神经递质甘氨酸是否参与VS的作用，通过鞘内导管将特定甘氨酸受体拮抗剂士的宁以1、5、25和100微克的剂量经脊柱周围给药。在给予士的宁之前，VS（400克力）提高了对不同强度尾部电击引发发声的阈值，并阻断了由先前经皮内注射20%酵母溶液致敏的皮肤区域刺激所引发的发声。给予士的宁后，VS的镇痛作用明显减弱。这些发现表明，VS的镇痛作用在脊髓水平上部分由甘氨酸介导。
