Roselli R J, Parker R E, Harris T R
Microvasc Res. 1985 May;29(3):320-39. doi: 10.1016/0026-2862(85)90022-6.
The multiple pore model of T. R. Harris and R. J. Roselli (1981, J. Appl. Physiol: Respir. Environ. Exercise Physiol. 50, 1-14), was used to simulate lung lymph flow and protein transport at various levels of microvascular pressure. Response of the three-pore structure determined in that study was found to be in excellent agreement with the experimental sheep lung lymph measurements of R. E. Parker, R. J. Roselli, T. R. Harris, and K. L. Brigham (1981, Circ. Res. 49, 1164-1172). Optimal one- and two-pore model structures were also determined and their responses compared with the experimental data. The two-pore model behavior was found to be very similar to that of the three-pore model but a homoporous model which reproduced the experimental findings could not be found. All simulations required interstitial fluid pressure to increase as microvascular pressure was elevated. True filtration-independent conditions could only be simulated when lung vascular pressures were raised to physiologically unrealistic values.
T. R. 哈里斯和R. J. 罗塞利（1981年，《应用生理学杂志：呼吸、环境与运动生理学》50卷，1 - 14页）的多孔隙模型，被用于模拟不同微血管压力水平下的肺淋巴液流动和蛋白质转运。研究发现，该研究中确定的三孔隙结构的反应，与R. E. 帕克、R. J. 罗塞利、T. R. 哈里斯和K. L. 布里格姆（1981年，《循环研究》49卷，1164 - 1172页）对绵羊肺淋巴液的实验测量结果高度吻合。还确定了最优的单孔隙和双孔隙模型结构，并将它们的反应与实验数据进行了比较。发现双孔隙模型的行为与三孔隙模型非常相似，但未能找到一个能再现实验结果的同孔隙模型。所有模拟都要求随着微血管压力升高，组织间液压力也升高。只有当肺血管压力升高到生理上不现实的值时，才能模拟真正的与滤过无关的情况。
