McNamee J E
Ann Biomed Eng. 1987;15(2):139-55. doi: 10.1007/BF02364050.
Mathematical models of solute and water exchange in the lung have been helpful in understanding factors governing the volume flow rate and composition of pulmonary lymph. As experimental data and models become more encompassing, parameter identification becomes more difficult. Pore sizes in these models should approach and eventually become equivalent to actual physiological pathway sizes as more complex and accurate models are tried. However, pore sizes and numbers vary from model to model as new pathway sizes are added. This apparent inconsistency of pore sizes can be explained if it is assumed that the pulmonary blood-lymph barrier is widely heteroporous, for example, being composed of a continuous distribution of pathway sizes. The sieving characteristics of the pulmonary barrier are reproduced by a log normal distribution of pathway sizes (log mean = -0.20, log s.d. = 1.05). A log normal distribution of pathways in the microvascular barrier is shown to follow from a rather general assumption about the nature of the pulmonary endothelial junction.
肺部溶质和水交换的数学模型有助于理解控制肺淋巴液体积流速和成分的因素。随着实验数据和模型变得更加全面，参数识别变得更加困难。随着尝试更复杂、更准确的模型，这些模型中的孔径应接近并最终等同于实际生理通路大小。然而，随着新的通路大小被加入，不同模型的孔径和数量各不相同。如果假设肺血 - 淋巴屏障具有广泛的异质性孔隙，例如由通路大小的连续分布组成，那么这种明显的孔径不一致就可以得到解释。肺屏障的筛分特性通过通路大小的对数正态分布（对数均值 = -0.20，对数标准差 = 1.05）来再现。微血管屏障中通路的对数正态分布表明是基于对肺内皮连接性质的一个相当普遍的假设得出的。
