Iwata Keiko, Noguchi Masafumi, Shintani Norihito
Laboratory of Pharmacology, School of Pharmaceutical Sciences, Wakayama Medical University, 25-1 Shichibancho, Wakayama 640-8156, Japan.
Biomolecules. 2025 Jan 27;15(2):184. doi: 10.3390/biom15020184.
Mitochondria are essential for brain function, and accumulating evidence from postmortem brain studies, neuroimaging, and basic research indicates mitochondrial impairments in patients with psychiatric disorders. Restoring mitochondrial function therefore represents a promising therapeutic strategy for these conditions. Mitochondrial transplantation, an innovative approach that uses functional mitochondria to repair damaged cells, has demonstrated efficacy through various delivery methods in cell, animal, and animal disease models. This review explores the critical link between mitochondria and psychiatric disorders and provides an overview of mitochondrial transplantation as a therapeutic intervention. It highlights recent advances in mitochondrial transplantation in animal models of psychiatric disorders, focusing on delivery methods, the timing of administration, and the integration of exogenous mitochondria into brain cells. The potential therapeutic effects and the mechanisms that underlie these effects are discussed. Additionally, this review evaluates the clinical relevance, challenges, and future strategies for the application of mitochondrial transplantation in the treatment of psychiatric disorders.
线粒体对大脑功能至关重要，来自尸检大脑研究、神经影像学和基础研究的越来越多的证据表明，精神疾病患者存在线粒体损伤。因此，恢复线粒体功能是针对这些病症的一种有前景的治疗策略。线粒体移植是一种利用功能性线粒体修复受损细胞的创新方法，已通过多种递送方式在细胞、动物和动物疾病模型中证明了其有效性。本综述探讨了线粒体与精神疾病之间的关键联系，并概述了线粒体移植作为一种治疗干预手段。它强调了精神疾病动物模型中线粒体移植的最新进展，重点关注递送方法、给药时间以及外源性线粒体融入脑细胞的情况。讨论了潜在的治疗效果及其背后的机制。此外，本综述评估了线粒体移植在精神疾病治疗应用中的临床相关性、挑战和未来策略。
