Liu Xiangli, Falconer Robert A
School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.
Bioengineering (Basel). 2025 Jan 30;12(2):133. doi: 10.3390/bioengineering12020133.
Cancer chemotherapeutics administered to cancer patients via traditional oral or parenteral routes often encounter poor bioavailability and severe systemic side effects. Skin delivery is a promising alternative route with reduced side effects and improved therapeutic efficacy and has gained significant attention in recent years. With conventional or deformable liposomal nanocarriers as a skin permeation strategy, cancer chemotherapeutics can be delivered via skin route, offering an option for more efficient therapy. This review summarizes the recent advances in liposome nanocarrier efficacy to enhance the skin delivery of chemotherapeutics with a wide range of physicochemical properties (log P from -0.89 to 5.93, MW from 130 to 1415) in targeting local skin cancer, breast cancer, and tumor metastasis and delivering the drug to systemic circulation to treat distal cancers. The potential mechanisms of skin permeation enhancement by different type of liposomes are also discussed in this review.
通过传统口服或肠胃外途径给予癌症患者的癌症化疗药物常常存在生物利用度低和严重的全身副作用问题。经皮给药是一种有前景的替代途径，具有副作用减少和治疗效果改善的特点，近年来受到了广泛关注。以传统或可变形脂质体纳米载体作为皮肤渗透策略，癌症化疗药物可以通过皮肤途径递送，为更有效的治疗提供了一种选择。本综述总结了脂质体纳米载体在增强化疗药物经皮递送方面的最新进展，这些化疗药物具有广泛的物理化学性质（log P从-0.89至5.93，分子量从130至1415），可用于靶向局部皮肤癌、乳腺癌和肿瘤转移，并将药物递送至体循环以治疗远端癌症。本综述还讨论了不同类型脂质体增强皮肤渗透的潜在机制。
