Bentaleb Malak, Abdulrahman Mohammed, Ribeiro Marcelo A F
College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Bioengineering (Basel). 2025 Jan 31;12(2):137. doi: 10.3390/bioengineering12020137.
Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise of antibiotic-resistant pathogens, it is crucial to develop new innovative wound materials to manage surgical wound infections using methods that facilitate drug delivery agents and rely on materials other than antimicrobials. Nanoparticles, in particular, have captured researchers' interest in recent years due to their effectiveness in wound care. They can be classified into three main types: inorganic nanoparticles, lipid-based nanoparticles, and polymeric nanoparticles. Several studies have demonstrated the effectiveness of these new technologies in enhancing wound-healing times and reducing bacterial burden. However, further research is essential to thoroughly evaluate the safety and toxicity of these materials before they can be integrated into routine surgical practice.
手术伤口感染是术后并发症的主要原因，会导致手术发病率和死亡率。随着抗生素耐药病原体的增加，开发新的创新伤口材料以采用促进药物递送剂并依赖抗菌剂以外的材料的方法来处理手术伤口感染至关重要。近年来，纳米颗粒因其在伤口护理中的有效性而引起了研究人员的关注。它们可分为三种主要类型：无机纳米颗粒、脂质基纳米颗粒和聚合物纳米颗粒。多项研究已证明这些新技术在缩短伤口愈合时间和减轻细菌负荷方面的有效性。然而，在将这些材料整合到常规手术实践之前，进行进一步研究以全面评估其安全性和毒性至关重要。
