In recent decades, the use of polypropylene meshes has been the gold standard in the surgical treatment of muscular corset failure. However, the reasons behind the low percentage of complications and recurrences remain controversial. Tissue hyperreactivity and the immune response to polypropylene may be contributing factors. Measurements of the level of hs-CRP (highly sensitive C-reactive protein) in the blood and morphometric studies of tissues around the implant were carried out for three months after the installation of polypropylene implants in 53 laboratory rats. The research results confirmed the good biocompatibility of polypropylene and the formation of full-fledged connective tissue around polypropylene three months after the installation of the material. The level of hs-CRP in the blood increased slightly, without significant differences, but in some animals, there was a sharp increase in this indicator at 3 months. Such results may indicate the development of hyperreactivity to the implantation of a synthetic material and, with other accompanying factors, lead to the development of complications both at the local tissue and general immune levels.