Grandone Elvira, Bitsadze Victoria, Khizroeva Jamilya, Chinni Elena, Mastroianno Mario, Nappi Luigi, Tretyakova Maria, Makatsariya Natalia, Grigoreva Kristina, Gashimova Nilufar, Lazarchuk Arina, Kapanadze Daredzhan, Polyakova Tatyana, Shatilina Anastasia, Lyadnova Elizaveta, Blbulyan Armen, Kuneshko Nart, Zainulina Marina, Gerotziafas Grigoris, Makatsariya Alexander
Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8-2, 119435 Moscow, Russia.
Thrombosis and Hemostasis Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
J Clin Med. 2025 Feb 7;14(4):1053. doi: 10.3390/jcm14041053.
This narrative review summarizes the available literature on the association between In Vitro Fertilization (IVF) treatments and thrombosis, focusing on epidemiology and pathophysiology. Thrombosis is a rare IVF-related complication, with an incidence of approximately 0.2%, dramatically increased by ovarian hyperstimulation syndrome (OHSS). Arterial thrombosis, primarily associated with OHSS, is a rare and early event, while venous thrombosis, although more common, remains a rare complication of IVF. Venous thrombosis often affects the upper body. The thrombotic risk is higher during the first trimester of pregnancy obtained through IVF. This review discusses the impact of risk factors such as OHSS, thrombophilia, obesity, advanced maternal age, and polycystic ovarian syndrome, which predispose women to thromboembolic events during and after IVF stimulation.
本叙述性综述总结了关于体外受精(IVF)治疗与血栓形成之间关联的现有文献,重点关注流行病学和病理生理学。血栓形成是一种罕见的与IVF相关的并发症,发病率约为0.2%,卵巢过度刺激综合征(OHSS)会使其显著增加。动脉血栓形成主要与OHSS相关,是一种罕见且发生较早的事件,而静脉血栓形成虽然更为常见,但仍是IVF的一种罕见并发症。静脉血栓形成常累及上半身。通过IVF受孕的妊娠头三个月血栓形成风险更高。本综述讨论了OHSS、血栓形成倾向、肥胖、高龄产妇和多囊卵巢综合征等风险因素的影响,这些因素使女性在IVF刺激期间及之后易发生血栓栓塞事件。