Gómez-Menchero Alberto, Royón-Gálvez Marina, Andrés-García Rodrigo, Herrero-Climent Mariano, Ríos-Carrasco Blanca, Fernandez-Palacín Fernando, Jaramillo-Santos Reyes
Department of Periodontology, Dental School, University of Seville, 41009 Seville, Spain.
Department of surgery, Medical School, Universtity of Salamanca; Patio de Escuelas, 1, 37008 Salamanca, Spain.
J Clin Med. 2025 Feb 9;14(4):1111. doi: 10.3390/jcm14041111.
: The aim of this study was to evaluate the clinical and radiological efficacy of minimally invasive surgical techniques for infraosseous defects by evaluating the effects of Emdogain (EMD) applied alone or with a xenograft, with a follow-up period of one year. : Forty patients with a combined total of forty-eight intraosseous defects participated in the research. Of these, 20 participants were treated with EMD (group 1), and 28 were treated with EMD and a xenograft (group 2). The clinical measurements probing depth (PD), recession (REC), and clinical attachment level (CAL) were assessed at six sites on the tooth. Additionally, the following intraoperative clinical measurements were taken: (1) distance from the cementoenamel junction (CEJ) to the bottom of the defect (CEJ-BD) and (2) distance from the CEJ to the most coronal extension of the interproximal bone crest (CEJ-BC). The infraosseous component of the defect was defined as INTRA = (CEJ-BD) - (CEJ-BC). : In comparison with the baseline, both treatment options showed statistically significant improvements in reducing PD and increasing CAL. The reduction in PD was 3.25 ± 0.786 mm for group 1 and 3.29 ± 1.013 mm for group 2. In terms of CAL gain, group 1 recorded a value of 4.65 ± 1.387 mm, compared with 5.07 ± 1.631 mm in group 2. Both groups showed a noticeable increase in radiographic bone filler, with an average of 69.85 ± 17.773%. : The two regeneration techniques were both effective for the treatment of deep intraosseous defects, encouraging more substantial filling compared with preoperative levels.
本研究的目的是通过评估单独使用釉基质蛋白（EMD）或联合异种移植物的效果，对骨下缺损的微创手术技术的临床和放射学疗效进行评估，随访期为一年。40例共有48处骨内缺损的患者参与了该研究。其中，20名参与者接受了EMD治疗（第1组），28名接受了EMD和异种移植物治疗（第2组）。在牙齿的六个部位评估临床测量指标探诊深度（PD）、退缩（REC）和临床附着水平（CAL）。此外，还进行了以下术中临床测量：（1）从牙骨质釉质界（CEJ）到缺损底部的距离（CEJ-BD）和（2）从CEJ到邻间骨嵴最冠方延伸处的距离（CEJ-BC）。缺损的骨下部分定义为INTRA =（CEJ-BD）-（CEJ-BC）。与基线相比，两种治疗方案在降低PD和增加CAL方面均显示出统计学上的显著改善。第1组PD的降低值为3.25±0.786mm，第2组为3.29±1.013mm。就CAL增加而言，第1组记录的值为4.65±1.387mm，而第2组为5.07±1.631mm。两组的放射学骨填充均有明显增加，平均为69.85±17.773%。这两种再生技术对治疗深部骨内缺损均有效，与术前水平相比，促进了更大量的填充。
