Ma Wenzhou, Hao Yujia, Peng Chengcheng, Zhang Duo, Yuan Yuge, Xiao Pengpeng, Li Nan
Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China.
College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Microorganisms. 2025 Jan 28;13(2):292. doi: 10.3390/microorganisms13020292.
The prevalence of SFTS is becoming increasingly widespread and is expected to become a significant security issue. The article discusses the prevalence regions and genetic differences in two SFTSV lineages, so as to provide a scientific data basis for the clinical control and prevention of fever with thrombocytopenia syndrome. The literature involving SFTSV patients from 2009 to 2023 and SFTSV complete genome sequences uploaded by NCBI were collected and sorted out, based on time and SFTSV lineage division, we analyzed viral gene sequence. SFTSV patient data were continuously reported from 2009 to 2023, involving five countries including China, South Korea, Japan, Thailand, and Vietnam. There are obvious lineage and host divisions between the SFTSV lineages prevalent in China and abroad. The sources of B-lineage SFTSV samples are mainly concentrated in South Korea, Japan, and the middle and lower reaches of Hubei or Zhejiang in China, with half of the samples coming from humans and half from animals, and the F series SFTSV samples were mainly collected from provinces such as Anhui and Henan in China, with the main source being human patients. The F-lineage SFTSV is the highest proportion in the middle and upper provinces in China. The B lineage has recently appeared in Zhejiang and Taiwan and is prevalent abroad. Using prediction software based on molecular structure prediction technology, analyze the differences between the B and F lineages of SFTSV through prediction methods such as nucleotide mutations, gene recombination, mutation sites, and evolution rates. Conclusively, the differences in SFTSV between B and F lineages may be related to gene recombination of M and L fragments, it was also found that the B lineage had a lower recombination rate and mutation rate than the F lineage, and the evolutionary rate was prominently different. Comparative analysis of the differences in two SFTSV lineage genes could further understand the epidemic status of SFTSV and provide help and more insights for the prevention of the spread of specific types of SFTSV.
发热伴血小板减少综合征（SFTS）的流行日益广泛，预计将成为一个重大的安全问题。本文讨论了两种SFTS病毒（SFTSV）谱系的流行区域和基因差异，以便为发热伴血小板减少综合征的临床防控提供科学数据依据。收集并整理了2009年至2023年涉及SFTSV患者的文献以及美国国立生物技术信息中心（NCBI）上传的SFTSV全基因组序列，基于时间和SFTSV谱系划分，我们对病毒基因序列进行了分析。2009年至2023年持续报告了SFTSV患者数据，涉及中国、韩国、日本、泰国和越南五个国家。国内外流行的SFTSV谱系之间存在明显的谱系和宿主划分。B谱系SFTSV样本来源主要集中在韩国、日本以及中国湖北中下游或浙江，样本一半来自人类，一半来自动物，而F系列SFTSV样本主要采集于中国安徽、河南等省份，主要来源是人类患者。F谱系SFTSV在中国中上游省份占比最高。B谱系最近在浙江和台湾出现并在国外流行。利用基于分子结构预测技术的预测软件，通过核苷酸突变、基因重组、突变位点和进化速率等预测方法分析SFTSV的B谱系和F谱系之间的差异。结论是，SFTSV的B谱系和F谱系之间的差异可能与M和L片段的基因重组有关，还发现B谱系的重组率和突变率低于F谱系，进化速率明显不同。对两种SFTSV谱系基因差异的比较分析可以进一步了解SFTSV的流行状况，并为预防特定类型的SFTSV传播提供帮助和更多见解。
