医护人员中麻疹、腮腺炎、风疹疫苗对严重急性呼吸综合征冠状病毒2的有效性和免疫原性

Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers.

作者信息

Seok Hyeri, Bae Joon-Yong, Kim Jooyun, Choi Won Suk, Park Heedo, Lee Jungmin, Lee Sohyun, Kim Chulwoo, Park Man-Seong, Park Dae Won

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea.

Department of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of Korea.

出版信息

Viruses. 2025 Feb 1;17(2):215. doi: 10.3390/v17020215.

DOI:10.3390/v17020215

PMID:40006970

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11860525/

Abstract

The purpose of this study was to evaluate the effectiveness and immunogenicity of the measles-mumps-rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). In addition, neutralizing antibodies to SARS-CoV-2 were measured according to the subjects' measles immunity status with serum samples collected before the coronavirus disease 2019 pandemic period. The effectiveness of the MMR vaccine for SARS-CoV-2 in all HCWs and measles IgG-positive subjects was 34% (adjusted odds ratio [aOR] = 1.20, 95% confidence interval [CI] = 0.53-2.70) and 34% (aOR = 0.66, CI = 0.38-18.4), respectively. The neutralizing antibody levels for SARS-CoV-2 were low in all groups regardless of the measles immune status. The MMR vaccine alone may not provide sufficient protection against SARS-CoV-2.

摘要

本研究的目的是评估在一家医疗机构中，麻疹-腮腺炎-风疹（MMR）疫苗对医护人员预防新型冠状病毒肺炎（SARS-CoV-2）的有效性和免疫原性。在全体医护人员（HCWs）中评估了MMR疫苗对SARS-CoV-2的有效性。此外，利用在2019冠状病毒病大流行期之前采集的血清样本，根据受试者的麻疹免疫状态测定了针对SARS-CoV-2的中和抗体。MMR疫苗对所有医护人员和麻疹IgG阳性受试者预防SARS-CoV-2的有效性分别为34%（校正比值比[aOR]=1.20，95%置信区间[CI]=0.53-2.70）和34%（aOR=0.66，CI=0.38-18.4）。无论麻疹免疫状态如何，所有组中针对SARS-CoV-2的中和抗体水平都很低。单独使用MMR疫苗可能无法提供足够的保护以预防SARS-CoV-2。