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药物技术部的研究。

Research in the Division of Pharmaceutical Technology.

作者信息

Junginger H E

出版信息

Pharm Weekbl Sci. 1985 Apr 26;7(2):59-62. doi: 10.1007/BF02106128.

DOI:10.1007/BF02106128
PMID:4000899
Abstract

Within the Center for Bio-Pharmaceutical Sciences the release characteristics of drugs form the major research object of the Division of Pharmaceutical Technology. Transdermal systems are being developed that can supply a drug during several days. Irritation of the skin may be avoided by using hydrogels. To enable long-term transdermal application also the colloidal structure of creams and ointments is investigated. As most drugs are to be taken orally, however, a research project was also started to make cheap and easy to produce controlled release tablets. The results with a microporous polypropylene polymer are promising.

摘要

在生物制药科学中心内,药物的释放特性是药物技术部门的主要研究对象。正在研发能在数天内持续给药的透皮系统。使用水凝胶可避免皮肤刺激。为实现长期透皮给药,还对乳膏和软膏的胶体结构进行了研究。然而,由于大多数药物需口服,因此还启动了一个研究项目,旨在生产廉价且易于制造的控释片剂。一种微孔聚丙烯聚合物的研究结果很有前景。

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本文引用的文献

1
Colloidal structures of O/W creams.
Pharm Weekbl Sci. 1984 Aug 24;6(4):141-9. doi: 10.1007/BF01954041.
2
Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application.
Br J Dermatol. 1985 Apr;112(4):461-7. doi: 10.1111/j.1365-2133.1985.tb02321.x.