一种超修饰核苷怀丁苷及其5'-单磷酸的酸催化水解动力学与机制
Kinetics and mechanism of the acid-catalyzed hydrolysis of a hypermodified nucleoside wyosine and its 5'-monophosphate.
作者信息
Golankiewicz B, Zielonacka-Lis E, Folkman W
出版信息
Nucleic Acids Res. 1985 Apr 11;13(7):2443-9. doi: 10.1093/nar/13.7.2443.
Abstract
The rates of acid-catalyzed hydrolysis of a hypermodified nucleoside, wyosine and its 5'-monophosphate were determined at various pH, temperature and buffer concentrations. The results show that despite distinct differences in structure and the glycosyl bond stability, the hydrolysis of wyosine proceeds via cleavage of the C-N bond by A-1 mechanism, analogously to simple nucleosides. Unlike majority of other monophosphates studied so far, wyosine 5'-monophosphate is not more stable than respective nucleoside.
摘要
在不同的pH值、温度和缓冲液浓度下，测定了一种超修饰核苷——肌苷及其5'-单磷酸的酸催化水解速率。结果表明，尽管肌苷在结构和糖苷键稳定性上存在明显差异，但其水解过程与简单核苷类似，通过A-1机制使C-N键断裂。与目前研究的大多数其他单磷酸不同，肌苷5'-单磷酸并不比相应的核苷更稳定。
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Kinetics and mechanism of the acid-catalyzed hydrolysis of a hypermodified nucleoside wyosine and its 5'-monophosphate.一种超修饰核苷怀丁苷及其5'-单磷酸的酸催化水解动力学与机制
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