Xu Qitong, Wang Huawei, Chen Ding, Yu Meng, Li Jun, Xie Chang, Cao Yan, Wang Lipan, Mei Surong
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
Hongshan District Center for Disease Control and Prevention, Wuhan, Hubei 430000, China.
Food Chem. 2025 Jun 15;477:143522. doi: 10.1016/j.foodchem.2025.143522. Epub 2025 Feb 19.
In this study, a novel hydroxyl-functionalized imidazolium-based ionic liquid introduced metal-organic framework (OH-IL@NH-MIL-53(Al)) was prepared for the extraction of multiple neonicotinoids (NEOs) and their metabolites. The functionalization of ionic liquid obviously enhanced the generate affinity of OH-IL@NH-MIL-53(Al) towards NEOs and their metabolites through the pre-designed hydrogen-bonding and cation-π electron donor-acceptor interactions. Adsorption studies of OH-IL@NH-MIL-53(Al) showed rapid adsorption rates and excellent adsorption capacities (129.3-204.2 mg/g). Furthermore, OH-IL@NH-MIL-53(Al)-based mix matrix membrane (MMM), named OH-IL@NH-MIL-53(Al)-MMM, was prepared for dispersive membrane extraction (DME). The supporting of MMM integrated the OH-IL@NH-MIL-53(Al) powder, greatly simplifying the extraction procedure. A OH-IL@NH-MIL-53(Al)-MMM-based DME-UPLC-MS/MS with good linearity (R ≥ 9987), low limits of detection (LODs, 0.001-0.120 ng/mL), and large enrichment factors (75-112) was developed. Based on the designed adsorbent, this work provides an easy and efficient method for the simultaneous analysis of fourteen NEOs and their metabolites in different samples and achieved satisfactory spiked recoveries (70.1-113.6 %).
在本研究中，制备了一种新型的引入金属有机框架的羟基官能化咪唑基离子液体（OH-IL@NH-MIL-53(Al)），用于萃取多种新烟碱类农药（NEOs）及其代谢物。离子液体的官能化通过预先设计的氢键和阳离子-π电子供体-受体相互作用，显著增强了OH-IL@NH-MIL-53(Al)对NEOs及其代谢物的亲和性。OH-IL@NH-MIL-53(Al)的吸附研究表明其具有快速的吸附速率和优异的吸附容量（129.3 - 204.2 mg/g）。此外，还制备了基于OH-IL@NH-MIL-53(Al)的混合基质膜（MMM），即OH-IL@NH-MIL-53(Al)-MMM，用于分散膜萃取（DME）。MMM的支撑作用整合了OH-IL@NH-MIL-53(Al)粉末，极大地简化了萃取过程。建立了一种基于OH-IL@NH-MIL-53(Al)-MMM的DME-UPLC-MS/MS方法，该方法具有良好的线性（R≥9987）、低检测限（LODs，0.001 - 0.120 ng/mL）和高富集因子（75 - 112）。基于所设计的吸附剂，本工作提供了一种简便高效的方法，用于同时分析不同样品中的十四种NEOs及其代谢物，并获得了令人满意的加标回收率（70.1 - 113.6%）。
