AlFada Mohammed, Alotaibi Hend, Alsharif Sahar, Alani Ahmad Hecham, Andrade-Miranda Andrea, Montesinos Guevara Camila, Chen Yaolong, Lei Ruobing, Acosta-Reyes Jorge, Velásquez-Salazar Pamela, El-Malky Ahmed, Amer Yasser S
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.
J Dermatolog Treat. 2025 Dec;36(1):2467751. doi: 10.1080/09546634.2025.2467751. Epub 2025 Feb 26.
The Appraisal of Guidelines for Research and Evaluation II Instrument (AGREE II) was developed to enhance the methodological rigor of clinical practice guidelines (CPGs), aiming to generate trustworthy recommendations for various clinical scenarios. Despite its importance, there exists a gap in the quality of CPGs pertaining to Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN). The aim of the study was to evaluate SJS-TEN CPGs to shed light on areas for enhancing SJS-TEN guidelines' quality.
A systematic review was conducted to identify SJS-TEN CPGs from January 2011 to December 2023 across bibliographic and guideline databases, as well as dermatology association websites. Four reviewers employed the AGREE II instrument to appraise the quality of eligible CPGs. Subsequently, AGREE II domain scores were calculated and their recommendations mapped.
Seven eligible SJS-TEN CPGs reviewed, originating from Europe, North America, Asia, and an authorship Group. The highest AGREE II domain scores were observed in scope and purpose (mean: 63%, standard deviation [SD]: 23.195%) and clarity of presentation (mean: 70%, SD: 14.5%). Conversely, the lowest score was noted in the applicability domain (mean: 28%, SD: 17.44%). Only two guidelines by the British Association of Dermatologists (28.6%) met the 'recommend' level. Recommendations from all CPGs were compared in tabular form.
研究与评估指南II工具（AGREE II）的开发旨在提高临床实践指南（CPG）的方法严谨性，旨在为各种临床场景生成可靠的建议。尽管其很重要，但关于史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症（SJS-TEN）的CPG质量仍存在差距。本研究的目的是评估SJS-TEN的CPG，以阐明提高SJS-TEN指南质量的领域。
进行了一项系统评价，以确定2011年1月至2023年12月期间跨书目和指南数据库以及皮肤病学协会网站的SJS-TEN CPG。四名评审员使用AGREE II工具评估符合条件的CPG的质量。随后，计算AGREE II领域得分并绘制其建议。
审查了七份符合条件的SJS-TEN CPG，它们来自欧洲、北美、亚洲和一个作者组。在范围和目的（平均：63%，标准差[SD]：23.195%）和表述清晰度（平均：70%，SD：14.5%）方面观察到最高的AGREE II领域得分。相反，适用性领域得分最低（平均：28%，SD：17.44%）。只有英国皮肤科医生协会的两份指南（28.6%）达到了“推荐”水平。所有CPG的建议以表格形式进行了比较。
