Herr Keira, Berk Michael, Huang Wei-Lieh, Kato Tadafumi, Lee Jung Goo, Ng Chong Guan, Wang Zhen, Webb Thomas, Kasahara-Kiritani Mami, Vandervoort Lawrence
Janssen Asia Pacific, Singapore, Singapore.
School of Medicine, Deakin University, Melbourne, Australia.
Neuropsychopharmacol Rep. 2025 Mar;45(1):e70007. doi: 10.1002/npr2.70007.
Anhedonia is a key symptom of major depressive disorder (MDD), however, its burden in patients with MDD is not well understood. We aimed to assess the impact of anhedonia on health-related quality of life (HRQoL), health-care resource utilization (HRU), and work productivity in subjects with MDD and anhedonia (MDD-ANH) compared to subjects with MDD without ANH (MDD non-ANH).
A cross-sectional web-based survey was conducted across six countries/territories. Adult participants were categorized as MDD-ANH, MDD non-ANH, and General Population based on self-reported MDD diagnosis, Patient Health Questionnaire (PHQ-9), and Snaith-Hamilton Pleasure Scale (SHAPS). Multivariate/generalized linear regression modeling (GLMs) and mediation analysis were used to assess anhedonia's impact on HRQoL/function, HRU, and work productivity.
Among 11 383 respondents, 20.1% were identified with MDD (MDD-ANH: 12.7%; MDD non-ANH: 7.3%) and 79.9% as General Population. Subjects with MDD-ANH, compared with MDD non-ANH demonstrated significantly worse or lower sexual functioning, HRQoL (RAND mental/physical component summary, health state utility (EuroQol) Index scores, all p < 0.001), and higher HRU (psychiatrist visits). Work productivity (higher absenteeism/overall work productivity or daily life impairment scores; all p < 0.05) was significantly worse in subjects with MDD-ANH compared with MDD non-ANH.
Anhedonia in patients with MDD had a significant negative impact on HRQoL, sexual functioning, work productivity, and HRU, emphasizing the need for focus on anhedonia management in MDD patients in the Asia-Pacific region.
快感缺失是重度抑郁症（MDD）的关键症状，然而，其在MDD患者中的负担尚未得到充分了解。我们旨在评估快感缺失对伴有快感缺失的MDD患者（MDD-ANH）与不伴有快感缺失的MDD患者（MDD非ANH）的健康相关生活质量（HRQoL）、医疗资源利用（HRU）和工作生产力的影响。
在六个国家/地区开展了一项基于网络的横断面调查。根据自我报告的MDD诊断、患者健康问卷（PHQ-9）和斯奈斯-汉密尔顿愉悦量表（SHAPS），将成年参与者分为MDD-ANH、MDD非ANH和一般人群。采用多变量/广义线性回归模型（GLMs）和中介分析来评估快感缺失对HRQoL/功能、HRU和工作生产力的影响。
在11383名受访者中，20.1%被诊断为MDD（MDD-ANH：12.7%；MDD非ANH：7.3%），79.9%为一般人群。与MDD非ANH相比，MDD-ANH患者的性功能、HRQoL（兰德精神/身体成分总结、健康状态效用（欧洲五维度健康量表）指数得分，均p<0.001）明显更差或更低，且HRU（精神科就诊次数）更高。与MDD非ANH相比，MDD-ANH患者的工作生产力（旷工率/总体工作生产力或日常生活受损得分更高；均p<0.05）明显更差。
MDD患者的快感缺失对HRQoL、性功能、工作生产力和HRU有显著负面影响，强调在亚太地区的MDD患者中需要关注快感缺失的管理。
