Rothausen Camilla S, Dieperink Karin B, Ruhlmann Christina H, Pappot Helle, Tolstrup Lærke K
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Department of Oncology, Odense University Hospital, Odense, Denmark.
Psychooncology. 2025 Mar;34(3):e70100. doi: 10.1002/pon.70100.
Immune checkpoint inhibitors (ICI) have improved cancer treatment, but this treatment can lead to immune-related adverse events (irAEs). Effective patient and caregiver education is essential to better management of irAEs and improved treatment outcomes.
This integrative review aimed to elucidate how patient education on ICI efficacy and toxicity management affects patients with cancer and their family caregivers' self-efficacy and self-management when dealing with irAEs.
An integrative review was conducted. EMBASE, MEDLINE, CINAHL, PsycINFO, and Scopus were searched for original research articles. Studies on educational interventions related to ICI and how it affects self-efficacy and self-management of irAEs were included. Data were analyzed using thematic analysis.
Of 4182 references screened; seven studies were included. Three themes emerged: (a) Feasibility of various strategies in patient education, (b) The effect of patient education on self-efficacy, and (c) Determinants to improve self-management of irAEs.
While traditional patient education methods (oral and/or written information) remain valuable, integrating digital technologies is promising to enhance understanding of ICI. Patient education, especially when combined with follow-up, can improve health-related quality of life and self-efficacy. However, health literacy plays a critical role in treatment and management of irAEs, emphasizing the need for personalized education approaches.
The protocol is registered with PROSPERO (No. CRD42024511513).
免疫检查点抑制剂（ICI）改善了癌症治疗，但这种治疗可能会导致免疫相关不良事件（irAE）。有效的患者及护理人员教育对于更好地管理irAE和改善治疗结果至关重要。
本综合综述旨在阐明关于ICI疗效和毒性管理的患者教育如何影响癌症患者及其家庭护理人员在应对irAE时的自我效能感和自我管理能力。
进行了一项综合综述。在EMBASE、MEDLINE、CINAHL、PsycINFO和Scopus数据库中检索原创研究文章。纳入了与ICI相关的教育干预措施及其如何影响irAE自我效能感和自我管理能力的研究。采用主题分析法对数据进行分析。
在筛选的4182篇参考文献中，纳入了7项研究。出现了三个主题：（a）患者教育中各种策略的可行性，（b）患者教育对自我效能感的影响，以及（c）改善irAE自我管理的决定因素。
虽然传统的患者教育方法（口头和/或书面信息）仍然很有价值，但整合数字技术有望增强对ICI的理解。患者教育，尤其是与随访相结合时，可以改善健康相关生活质量和自我效能感。然而，健康素养在irAE的治疗和管理中起着关键作用，这强调了个性化教育方法的必要性。
该方案已在PROSPERO注册（编号CRD42024511513）。
