Querry Manon, Botzung Anne, Sourty Marion, Chabran Elena, Sanna Léa, Loureiro de Sousa Paulo, Cretin Benjamin, Demuynck Catherine, Muller Candice, Ravier Alix, Schorr Benoît, Philippi Nathalie, Blanc Frédéric
University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, Strasbourg, France.
Geriatrics Division, University Hospitals of Strasbourg, CM2R (Research and Resources Memory Centre), Geriatric Day Hospital, Strasbourg, France.
Int J Geriatr Psychiatry. 2025 Mar;40(3):e70058. doi: 10.1002/gps.70058.
Depressive symptoms are frequent in the early stages of dementia with Lewy bodies (DLB), and more than half of DLB patients would have a history of depression. Our study sought to investigate the functional connectivity (FC) changes associated with depressive symptoms in prodromal to mild DLB patients compared with controls.
MRI data were collected from 66 DLB patients and 18 controls. Depression was evaluated with the Mini International Neuropsychiatric Interview. Resting-state FC (rsFC) was investigated with the CONN toolbox using a seed-based approach and both regression and comparison analyses.
Correlations were found between the depression scores and the rsFC between fronto-temporal and primary visual areas in DLB patients (p < 0.05, FDR corrected). Depressed DLB patients also showed decreased rsFC within the salience network (SN), increased rsFC between the default mode network (DMN) and the language network (LN) and decreased rsFC between the cerebellar network (CN) and the fronto-parietal network (FPN) compared to non-depressed DLB patients (p < 0.05, uncorrected). Comparison analyses between antidepressant-treated and non-treated DLB patients highlighted FC changes in treated patients involving the SN, the DMN, the FPN and the dorsal attentional network (p < 0.05, uncorrected).
Our findings revealed that depressive symptoms would especially be associated with rsFC changes between fronto-temporal and primary visual areas in DLB patients. Such alterations could contribute to difficulties in regulating emotions, processing biases towards negative stimuli, and self-focused ruminations.
This study is part of the cohort study AlphaLewyMA (https://clinicaltrials.gov/ct2/show/NCT01876459).
路易体痴呆（DLB）早期阶段抑郁症状常见，超过半数的DLB患者有抑郁病史。我们的研究旨在调查前驱期至轻度DLB患者与对照组相比，与抑郁症状相关的功能连接（FC）变化。
收集了66例DLB患者和18例对照的MRI数据。使用迷你国际神经精神访谈评估抑郁情况。使用CONN工具箱采用基于种子的方法以及回归和比较分析来研究静息态FC（rsFC）。
在DLB患者中，抑郁评分与额颞叶和初级视觉区域之间的rsFC存在相关性（p<0.05，经FDR校正）。与未抑郁的DLB患者相比，抑郁的DLB患者在突显网络（SN）内的rsFC也降低，默认模式网络（DMN）和语言网络（LN）之间的rsFC增加，小脑网络（CN）和额顶叶网络（FPN）之间的rsFC降低（p<0.05，未校正）。抗抑郁治疗和未治疗的DLB患者之间的比较分析突出了治疗患者中涉及SN、DMN、FPN和背侧注意网络的FC变化（p<0.05，未校正）。
我们的研究结果表明，抑郁症状尤其与DLB患者额颞叶和初级视觉区域之间的rsFC变化有关。这种改变可能导致情绪调节困难、对负面刺激的加工偏差以及自我专注的沉思。
本研究是队列研究AlphaLewyMA（https://clinicaltrials.gov/ct2/show/NCT01876459）的一部分。
