Thomas G, Voigt R
Pharmazie. 1985 Feb;40(2):113-4.
Propyphenazone has been recrystallized from different polarity solvents by means of various non-ionic tensides (Tween 20 and 80, Brij 35 and Myrj 51) and the ionic sodium lauryl sulphate. The tenside amount adsorbed by propyphenazone could be determined by measurements of the surface tension. Differences between the adsorption of the non-ionic tensides and the ionic product could be stated. Differences of the crystal areas can be eliminated by adding tensides to polar and apolar solvents. All the recrystallization products distinguish by a significant increase of the dissolution rate.
通过各种非离子表面活性剂（吐温20和80、Brij 35和Myrj 51）以及离子型十二烷基硫酸钠，将保泰松从不同极性的溶剂中重结晶。保泰松吸附的表面活性剂用量可通过表面张力测量来确定。可以说明非离子表面活性剂和离子型产品在吸附方面的差异。通过向极性和非极性溶剂中添加表面活性剂，可以消除晶体面积的差异。所有重结晶产物的溶解速率都有显著提高。
