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临床问题解决:一名67岁男性,腿部疼痛、无力且行走困难。

Clinical Problem Solving: A 67-year-old Man With Painful Leg Weakness and Difficulty Walking.

作者信息

Verity Ryan, Raynor Elizabeth, Zuflacht Jonah

机构信息

Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada.

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

出版信息

Neurohospitalist. 2025 Feb 24:19418744251324078. doi: 10.1177/19418744251324078.

DOI:10.1177/19418744251324078
PMID:40013086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11851592/
Abstract

Rapidly progressive neurologic symptoms can be alarming to both the patient and the clinician, given the concern for serious pathologies. In this case, a 67-year-old patient presents with painful sensorimotor symptoms that progress rapidly within days of onset. Proper localization and consideration of medical co-morbidities is essential for accurate diagnosis. This case highlights the importance of a detailed neurologic examination to aid in the localization and differential diagnosis. The case will take readers through a stepwise approach to this complex neurologic presentation, work-up and management.

摘要

快速进展的神经系统症状可能会让患者和临床医生都感到担忧,因为担心存在严重病变。在本病例中,一名67岁患者出现疼痛性感觉运动症状,起病数天内迅速进展。正确定位并考虑合并的内科疾病对于准确诊断至关重要。本病例强调了详细的神经系统检查对于辅助定位和鉴别诊断的重要性。该病例将引导读者逐步了解这种复杂的神经系统表现、检查及管理。

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本文引用的文献

1
Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report.克拉霉素诱发的嗜酸性肉芽肿性多血管炎:一例报告。
Respir Med Case Rep. 2023 May 31;44:101878. doi: 10.1016/j.rmcr.2023.101878. eCollection 2023.
2
Two cases with new onset of ANCA-positive eosinophilic granulomatosis with polyangiitis under treatment with dupilumab: coincidence or causality?两例新发抗中性粒细胞胞浆抗体(ANCA)阳性的嗜酸性肉芽肿性多血管炎患者正在接受度普利尤单抗治疗:是巧合还是存在因果关系?
Ann Rheum Dis. 2023 Apr;82(4):580-582. doi: 10.1136/ard-2022-223596. Epub 2022 Dec 20.
3
A Review of Anti-IL-5 Therapies for Eosinophilic Granulomatosis with Polyangiitis.嗜酸性肉芽肿性多血管炎的抗白细胞介素-5疗法综述
Adv Ther. 2023 Jan;40(1):25-40. doi: 10.1007/s12325-022-02307-x. Epub 2022 Sep 24.
4
ANCA-Associated Vasculitic Neuropathies: A Review.抗中性粒细胞胞浆抗体相关血管炎性神经病:综述
Neurol Ther. 2022 Mar;11(1):21-38. doi: 10.1007/s40120-021-00315-7. Epub 2022 Jan 19.
5
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.2021 年美国风湿病学会/血管炎基金会抗中性粒细胞胞浆抗体相关性血管炎治疗指南。
Arthritis Rheumatol. 2021 Aug;73(8):1366-1383. doi: 10.1002/art.41773. Epub 2021 Jul 8.
6
Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA.EGPA 相关性神经病伴与不伴 ANCA 的临床病理差异特征。
Neurology. 2020 Apr 21;94(16):e1726-e1737. doi: 10.1212/WNL.0000000000009309. Epub 2020 Mar 26.
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Eur Respir J. 2000 May;15(5):978-81. doi: 10.1034/j.1399-3003.2000.15e29.x.
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Lancet. 1999 Feb 27;353(9154):725-6. doi: 10.1016/S0140-6736(99)00565-6.
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