Yeo Gaeun, Kim Jaeyun
School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Biomacromolecules. 2025 Mar 10;26(3):1627-1638. doi: 10.1021/acs.biomac.4c01442. Epub 2025 Feb 27.
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, oxidative stress, and immune dysregulation. In this study, we developed a multifunctional, double-network hydrogel, composed of chitosan and poly(acrylic acid), embedded with cerium oxide nanoparticles (CeNPs) and betamethasone. The hydrogel harnesses the redox-catalytic properties of CeNPs to scavenge reactive oxygen species (ROS) while ensuring sustained betamethasone release for antibacterial and anti-inflammatory effects. Its mechanical stability and high water retention make it suitable for long-term skin application. In vitro, the hydrogel enhanced keratinocyte viability under oxidative stress and showed significant antibacterial activity against . In a psoriasis-induced mouse model, the hydrogel significantly reduced epidermal hyperplasia, suppressed keratinocyte proliferation, and lowered inflammatory cytokine levels. The combination of antioxidant, antibacterial, and anti-inflammatory properties suggests that this hydrogel offers a promising therapeutic strategy for psoriasis, addressing both oxidative stress and inflammation for effective treatment.
银屑病是一种慢性炎症性皮肤病，其特征为角质形成细胞过度增殖、氧化应激和免疫失调。在本研究中，我们开发了一种多功能双网络水凝胶，它由壳聚糖和聚丙烯酸组成，并嵌入了氧化铈纳米颗粒（CeNPs）和倍他米松。该水凝胶利用CeNPs的氧化还原催化特性来清除活性氧（ROS），同时确保倍他米松的持续释放以发挥抗菌和抗炎作用。其机械稳定性和高保水性使其适用于长期皮肤应用。在体外，该水凝胶在氧化应激下提高了角质形成细胞的活力，并对……显示出显著的抗菌活性。在银屑病诱导的小鼠模型中，该水凝胶显著减少了表皮增生，抑制了角质形成细胞增殖，并降低了炎症细胞因子水平。抗氧化、抗菌和抗炎特性的结合表明，这种水凝胶为银屑病提供了一种有前景的治疗策略，可同时解决氧化应激和炎症问题以实现有效治疗。
