Khurshid Sidra, Saeed Aruba, Kashif Muhammad, Nasreen Aniqa, Riaz Huma
Riphah College of Rehabilitation and Allied Health Sciences, Riphah International University, Lahore Campus, Islamabad, Pakistan.
Faculty of Rehabilitation Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.
BMC Neurosci. 2025 Feb 27;26(1):16. doi: 10.1186/s12868-024-00924-6.
Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, is associated with peripheral nerve damage, leading to balance impairments, postural instability, and reduced mobility. Addressing these challenges requires comprehensive interventions that target multiple deficits simultaneously. Evidence suggests that exercise programs combining balance, proprioception, strength, and reaction time training can improve postural stability, enhance mobility, and alleviate pain in individuals with DPN.
The objective of this study was to compare the effects of multisystem exercises and conventional exercises on balance, postural stability, mobility, and walking speed and to reduce pain in patients with diabetic peripheral neuropathy.
This double-blinded, two-arm parallel design randomized controlled trial was conducted at DHQ Hospital, Pakpattan, Pakistan. A total of 50 participants who met the inclusion criteria were recruited using the nonprobability convenience sampling technique. They were randomly assigned to either a multisystem physical exercise (MPE) group (n = 26) and a conventional exercise group (n = 24). The MPE program included balance, proprioception, strength, and reaction time training, while the control group received conventional exercises, consisted of strength, balance, stretching, and range of motion exercises. Both groups underwent 30 min intervention sessions, 3 times per week, for 8 weeks. The outcome measures used for assessing the balance, postural stability, mobility, and pain included the Berg balance scale (BBS), functional reach test (FRT), time up and go test (TUG), 10 min walk test (10-MWT), and numeric pain rating scale (NPRS). The data was analyzed using SPSS version 26.
Significant group and time interactions were observed for all outcome measures including BBS, FRT, TUG, 10-MWT, and NPRS (p < 0.001). The between-group analysis also revealed significant differences between the multisystem physical exercise group and the conventional exercise group at both the 4th week and 8th week for BBS, FRT, TUG, 10-MWT, and NPRS (p < 0.05).
The study concluded that multisystem exercises resulted in significant improvement in balance, postural stability, mobility, and walking speed, along with reduction in pain, compared to conventional exercises in patients with diabetic peripheral neuropathy.
This randomized controlled study was registered prospectively on November 11th, 2023 with the ClinicalTrials.gov (NCT06130917).
糖尿病周围神经病变（DPN）是糖尿病常见的并发症，与周围神经损伤有关，可导致平衡功能障碍、姿势不稳和活动能力下降。应对这些挑战需要同时针对多种缺陷的综合干预措施。有证据表明，结合平衡、本体感觉、力量和反应时间训练的运动计划可以改善DPN患者的姿势稳定性、增强活动能力并减轻疼痛。
本研究的目的是比较多系统运动和传统运动对糖尿病周围神经病变患者平衡、姿势稳定性、活动能力和步行速度的影响，并减轻其疼痛。
这项双盲、双臂平行设计的随机对照试验在巴基斯坦帕克帕坦的DHQ医院进行。采用非概率便利抽样技术招募了50名符合纳入标准的参与者。他们被随机分配到多系统体育锻炼（MPE）组（n = 26）和传统运动组（n = 24）。MPE计划包括平衡、本体感觉、力量和反应时间训练，而对照组接受由力量、平衡、伸展和关节活动度练习组成的传统运动。两组均进行30分钟的干预课程，每周3次，共8周。用于评估平衡、姿势稳定性、活动能力和疼痛的结局指标包括伯格平衡量表（BBS）、功能性伸展测试（FRT）、起立行走测试（TUG）、10分钟步行测试（10-MWT）和数字疼痛评分量表（NPRS）。使用SPSS 26版对数据进行分析。
在包括BBS、FRT、TUG、10-MWT和NPRS在内的所有结局指标上均观察到显著的组间和时间交互作用（p < 0.001）。组间分析还显示，在第4周和第8周时，多系统体育锻炼组和传统运动组在BBS、FRT、TUG、10-MWT和NPRS方面均存在显著差异（p < 0.05）。
该研究得出结论，与传统运动相比，多系统运动能使糖尿病周围神经病变患者的平衡、姿势稳定性、活动能力和步行速度得到显著改善，同时减轻疼痛。
这项随机对照研究于2023年11月11日在ClinicalTrials.gov（NCT06130917）上进行了前瞻性注册。
