Checkoway H, Waldman G T
Scand J Work Environ Health. 1985 Apr;11(2):131-3. doi: 10.5271/sjweh.2243.
Case-referent studies nested within occupational cohort studies are efficient designs for estimating relative risks associated with exposures and for obtaining data on nonoccupational confounding factors. Frequently, however, only incomplete data on confounders can be obtained from sources such as next-of-kin or co-workers. A method for assessing the potential extent of confounding in cohort studies described previously by Axelson [Scand J Work Environ Health 4 (1978) 98-102] can be adapted for use in nested case-referent studies. An example is shown to illustrate that the adapted Axelson method is preferable to the usual confounder adjustment techniques when data on the confounder are incomplete.
嵌套于职业队列研究中的病例对照研究是用于估计与暴露相关的相对风险以及获取非职业性混杂因素数据的有效设计。然而，通常只能从亲属或同事等来源获得关于混杂因素的不完整数据。Axelson先前描述的一种评估队列研究中潜在混杂程度的方法[《斯堪的纳维亚工作环境与健康杂志》4 (1978) 98 - 102]可适用于嵌套病例对照研究。给出一个例子来说明，当关于混杂因素的数据不完整时，经改编的Axelson方法比常用的混杂因素调整技术更可取。
