Khiatah Bashar, Jazayeri Sam, Diep Brian, Yamamoto Naofumi, Belikova Anna, Diaz Graal, Frugoli Amanda, Mansour Craig
Department of Internal Medicine, Overlake Medical Center, Bellevue, WA.
Department of Research and Statistics, Community Memorial Hospital, Ventura, CA.
Medicine (Baltimore). 2025 Feb 28;104(9):e41614. doi: 10.1097/MD.0000000000041614.
The natural forces of the lunar cycle and seasonal solstice variation on the water surfaces have been studied extensively but not on patients with fluid problems such as heart failure (HF). This retrospective review investigates these temporal effects on admission rates of patients with heart failure and length of stay. In this study, we try to answer the following questions: Do moon cycles (full moon vs new moon) significantly affect the number of patients admitted? and Do moon cycles significantly affect the patient's hospital length of stay (LOS?). All patients with HF exacerbation admission between January 1, 2016 to December 31, 2019, were filtered according to admission date based on the lunar calendar. Patients admitted on the day of, the day before, and the day after a new and full moon were included. Question 1, Poisson regression models were employed. The overdispersion obtained from the AER package was 1.63. All analyses were performed using R (R Core Team). A total of 758 patients were admitted during lunar cycles, 50.1% (N = 380) were admitted during the new moon and 49.4% (N = 378) during the full moon. The mean age is 78.4 (SD 7.2), the mean BMI is 28.8 (SD 6.7), and the mean LOS is 5.6 (SD 3.4) with no significant differences in patients admitted during both of the moon cycles. The seasons variable showed statistically significant coefficients, with the summer season (S2) having the highest impact (coefficient 0.85, P = .001). Some interaction between Moon-Cycle, summer season, and BMI influenced patient admissions during lunar cycles (coefficient = 0.49 P ≤ .001). This study showed that the moon cycle may impact patients with HF during the summer season only. Prospective studies are needed on a national level to investigate further the impact of the moon cycle on HF patients. This will help improve patient outcomes and pathogenesis, and there is excellent potential for reducing medical costs.
人们对月球周期和季节冬至变化对水面的自然作用力进行了广泛研究，但尚未针对心力衰竭（HF）等有体液问题的患者进行研究。这项回顾性研究调查了这些时间因素对心力衰竭患者入院率和住院时间的影响。在本研究中，我们试图回答以下问题：月球周期（满月与新月）是否会显著影响入院患者数量？以及月球周期是否会显著影响患者的住院时间（LOS）？对2016年1月1日至2019年12月31日期间因心力衰竭加重入院的所有患者，根据农历的入院日期进行筛选。纳入在新月和满月当天、前一天和后一天入院的患者。问题1采用泊松回归模型。从AER软件包获得的过度离散值为1.63。所有分析均使用R（R核心团队）进行。在月球周期期间共有758名患者入院，其中50.1%（N = 380）在新月期间入院，49.4%（N = 378）在满月期间入院。平均年龄为78.4（标准差7.2），平均体重指数为28.8（标准差6.7），平均住院时间为5.6（标准差3.4），在两个月球周期期间入院的患者之间无显著差异。季节变量显示出具有统计学意义的系数，夏季（S2）影响最大（系数0.85，P = .001）。月球周期、夏季和体重指数之间的一些相互作用影响了月球周期期间的患者入院情况（系数 = 0.49，P≤.001）。本研究表明，月球周期可能仅在夏季对心力衰竭患者产生影响。需要在全国范围内进行前瞻性研究，以进一步调查月球周期对心力衰竭患者的影响。这将有助于改善患者的治疗效果和发病机制，并且在降低医疗成本方面具有巨大潜力。
