Vajda J, Branston N M, Ladds A, Symon L
Stroke. 1985 May-Jun;16(3):493-501. doi: 10.1161/01.str.16.3.493.
A model for studying changes in local CBF and evoked potentials in selective thalamic ischaemia has been developed. The arterial supply to the posterior thalamus (mainly from the posterior choroidal arteries) was occluded in the baboon using a transorbital approach to the region of prepontine and ambient cisterns. Local CBF was measured by the hydrogen clearance method using electrodes introduced into the nucleus ventralis posterior lateralis of thalamus as well as cortex on both sides. The production of focal ischaemia was demonstrated by a significant decrease in thalamic CBF and confirmed by examination of the brain perfused with carbon particles.
已开发出一种用于研究选择性丘脑缺血时局部脑血流量(CBF)变化和诱发电位的模型。使用经眶入路到达脑桥前池和环池区域,阻断狒狒丘脑后部的动脉供应(主要来自脉络膜后动脉)。通过将电极插入丘脑腹后外侧核以及双侧皮质,采用氢清除法测量局部脑血流量。丘脑CBF显著降低证明了局灶性缺血的产生,并用灌注碳颗粒的脑检查予以证实。