Aydın Siyami
Department of Thoracic Surgery, Firat University, Medicine Faculty, Elazig, Turkey.
Asian Pac J Cancer Prev. 2025 Feb 1;26(2):399-403. doi: 10.31557/APJCP.2025.26.2.399.
Lung cancer is the most common cancer with the highest mortality rate. Spexin peptide acts as a potential regulatory factor in glucose and energy metabolism in this cancer type. It has been reported that TRPM2 ion channel is formed by oxidative stress and stimulates Ca2++ influx in cancer patients.
In our study, we aimed to immunohistochemically determine the activity levels of Spexin peptide and TRPM2 ion channels in lung cancer patients and to differentiate their levels according to cancer type.
To determine the effects of these peptides and ion channels in lung cancer, 30 cases with lung cancer and 30 randomised control groups were formed. The activity levels of Spexin peptide and TRPM2 ion channels in different types of lung cancer and non-cancerous groups were compared.
The study examined lung cancer subtypes (Adeno Ca, SCC, and Small Cell Ca) and a control group. Spexin and TRPM2 levels were significantly higher in Adeno Ca and SCC compared to controls and Small Cell Ca. Small Cell Ca showed no significant difference from controls. No differences were found between Adeno Ca and SCC.
Immunoreactivity levels of these markers were found to be higher in adenocarcinoma and squamous cell lung cancer tissues than in small cell cancer and non-cancerous tissues. In conclusion, spexin and TRPM2 ion channel levels can be evaluated as a marker in adenocarcinoma and squamous cell lung cancer.
肺癌是最常见且死亡率最高的癌症。Spexin肽在这种癌症类型的葡萄糖和能量代谢中充当潜在的调节因子。据报道，TRPM2离子通道由氧化应激形成，并刺激癌症患者的Ca2+内流。
在我们的研究中，我们旨在通过免疫组织化学方法测定肺癌患者中Spexin肽和TRPM2离子通道的活性水平，并根据癌症类型区分它们的水平。
为了确定这些肽和离子通道在肺癌中的作用，组建了30例肺癌患者和30个随机对照组。比较了不同类型肺癌组和非癌组中Spexin肽和TRPM2离子通道的活性水平。
该研究检查了肺癌亚型（腺癌、鳞状细胞癌和小细胞癌）以及一个对照组。与对照组和小细胞癌相比，腺癌和鳞状细胞癌中的Spexin和TRPM2水平显著更高。小细胞癌与对照组之间无显著差异。腺癌和鳞状细胞癌之间未发现差异。
发现这些标志物在腺癌和鳞状细胞肺癌组织中的免疫反应性水平高于小细胞癌和非癌组织。总之，Spexin和TRPM2离子通道水平可作为腺癌和鳞状细胞肺癌的一个标志物进行评估。
