CTLA-4在弥漫性大B细胞淋巴瘤中的不同免疫组化表达及其相关预后因素
Different Immunohistochemical Expression of CTLA-4 in Diffuse Large B-Cell Lymphoma and Its Associated Prognostic Factors.
作者信息
Rifani Liyona, Ham Maria Francisca, Khoirunnisa Dina, Harahap Agnes Stephanie
机构信息
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta 14320, Indonesia.
Human Cancer Research Center-Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta 14320, Indonesia.
出版信息
Asian Pac J Cancer Prev. 2025 Feb 1;26(2):405-410. doi: 10.31557/APJCP.2025.26.2.405.
BACKGROUND
Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center B-cell-like (GCB) and non-GCB subtypes. This study aimed to evaluate the immunohistochemical expression of CTLA-4 in these subtypes and its association with prognostic factors.
METHODS
This retrospective study analyzed 50 cases of DLBCL. Clinical and histopathological data were collected, and CTLA-4 expression was assessed using immunohistochemistry. Statistical significance was determined using an unpaired t-test.
RESULT
The average CTLA-4 expression in DLBCL was 50.46 cells per high-power field. Higher CTLA-4 expression was observed in the non-GCB subtype, patients younger than 60 years, females, those with stage III-IV disease, involvement of more than one extranodal site, and a low International Prognostic Index (IPI) score (0-2). A significant association was found between CTLA-4 expression and age (p = 0.045, 95% CI: 44.67-75.86).
CONCLUSION
CTLA-4 expression was present in the tumor microenvironment of DLBCL. Higher expression was significantly associated with patients younger than 60 years.
背景
弥漫性大B细胞淋巴瘤（DLBCL）分为生发中心B细胞样（GCB）和非GCB亚型。本研究旨在评估CTLA-4在这些亚型中的免疫组化表达及其与预后因素的关联。
方法
本回顾性研究分析了50例DLBCL病例。收集临床和组织病理学数据，并采用免疫组化评估CTLA-4表达。采用非配对t检验确定统计学意义。
结果
DLBCL中CTLA-4的平均表达为每高倍视野50.46个细胞。在非GCB亚型、年龄小于60岁的患者、女性、疾病分期为III-IV期、累及一个以上结外部位以及国际预后指数（IPI）评分低（0-2）的患者中观察到较高的CTLA-4表达。发现CTLA-4表达与年龄之间存在显著关联（p = 0.045，95%CI：44.67-75.86）。
结论
CTLA-4表达存在于DLBCL的肿瘤微环境中。较高表达与年龄小于60岁的患者显著相关。
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