A narrative review on the use of Green synthesized metallic nanoparticles for targeted cancer therapy.

Cancer is a leading cause of death worldwide. While traditional and synthetic medical therapies are in place for cancer treatment, their effectiveness is hindered by various limitations, such as toxic side effects, limited availability, and high costs. In recent years, a promising alternative approach has emerged in the form of green-synthesized metallic nanoparticles (MNPs), which offer targeted cancer therapy. These nanoparticles (NPs) have garnered significant attention from cancer researchers owing to their natural or surface-induced anticancer properties, versatility of metals as agents, and eco-friendly nature. This approach may positively impact healthy cells surrounding the cancerous cells. Green-synthesized MNPs have gained popularity in cancer management because of their ease of handling in the laboratory and the affordability of starting materials compared to synthetic methods. This review analyzes green-synthesized MNPs for targeted cancer therapy, highlighting tumor-targeting strategies, synthesis methods, and clinical challenges. Unlike general reviews, it compares plant-, microbial-, and enzyme-mediated synthesis approaches, emphasizing their impact on nanoparticle stability, functionalization, and interactions with the tumor microenvironment for enhanced therapeutic efficacy.