Ruojing Liu, Ruizhi Li, Zhuo Chen, Shujuan Zou, Jingtao Li, Xing Yin
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Plast Reconstr Aesthet Surg. 2025 Apr;103:264-272. doi: 10.1016/j.bjps.2025.01.061. Epub 2025 Jan 29.
To explore if the nasal profile is influenced by maxillary hypoplasia among patients with congenital cleft lip and palate.
Young adult patients with cleft and noncleft controls were enrolled. Nasal and maxillary profiles were measured on lateral cephalometric radiographs. The Kruskal-Wallis and Tukey post-hoc tests were employed for intergroup comparison among various the cleft types, and Pearson's product moment correlation coefficients were calculated to detect the correlation between nasal and maxillary cephalometric measurements.
A total of 250 participants were enrolled, including 64 with unilateral cleft lip and alveolae; 22 with bilateral cleft lip and alveolae; 49 with unilateral cleft lip, alveolae, and palate; 35 with bilateral cleft lip, alveolae, and palate; and 80 controls. Patients with cleft demonstrated significant difference in nasal and maxillary profiles when compared with the normal controls. The nasal dorsum length had a significant positive correlation with anterior and posterior maxillary height. The upper nasal dorsum length had a significant negative correlation with the maxillary protrusion. Among patients with bilateral cleft, the nasal dorsum length was also significantly negatively correlated with the maxillary protrusion.
The nasal profile is closely related to the growth of maxillae among patients with cleft and the normal population.
探讨先天性唇腭裂患者中鼻外形是否受上颌骨发育不全的影响。
纳入年轻成年唇腭裂患者及非唇腭裂对照者。在头颅侧位片上测量鼻和上颌的外形。采用Kruskal-Wallis检验和Tukey事后检验对不同腭裂类型进行组间比较，并计算Pearson积矩相关系数以检测鼻和上颌头颅测量值之间的相关性。
共纳入250名参与者，包括64名单侧唇腭裂患者；22名双侧唇腭裂患者；49名单侧唇腭裂伴牙槽突裂患者；35名双侧唇腭裂伴牙槽突裂患者；以及80名对照者。与正常对照相比，唇腭裂患者在鼻和上颌外形上存在显著差异。鼻背长度与上颌前后高度呈显著正相关。鼻背上段长度与上颌前突呈显著负相关。在双侧唇腭裂患者中，鼻背长度与上颌前突也呈显著负相关。
唇腭裂患者及正常人群的鼻外形与上颌骨的生长密切相关。
