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温室工人染色体畸变的发生率及其淋巴细胞对双甲脒细胞遗传学作用的体外敏感性

[Incidence of chromosome aberrations in hothouse workers and the in vitro sensitivity of their lymphocytes to the cytogenetic action of dimatif].

作者信息

Pilinskaia M A

出版信息

Tsitol Genet. 1985 Mar-Apr;19(2):124-8.

PMID:4002335
Abstract

The cytogenetical survey of eight persons working in greenhouse and occupationally contacting with a complex of pesticides has shown a significant increase of chromosomal aberration level in comparison with the control group. It is determined that the cytogenetic effect of the greenhouse's workers differed significantly from that of the control group when lymphocytes of the examined persons were treated by the potent mutagen dimatyph in vitro. The occupational group on the whole was more sensitive than control persons to the clastogenic action of dimatyph (43.0 +/- 2.2 and 28.7 +/- 2.4%, respectively). An assumption is advanced on the modifying influence of the pesticide complex on the frequency of induced chromosomal aberrations in vitro.

摘要

对8名在温室工作且职业性接触多种农药的人员进行的细胞遗传学调查显示，与对照组相比，其染色体畸变水平显著升高。已确定，当用强效诱变剂二甲基亚砜对受检人员的淋巴细胞进行体外处理时，温室工作人员的细胞遗传学效应与对照组有显著差异。总体而言，职业组比对照组对二甲基亚砜的致断裂作用更敏感（分别为43.0±2.2%和28.7±2.4%）。有人提出了关于农药复合物对体外诱导染色体畸变频率的修饰作用的假设。

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