Jacquet J, Marcos E, Lipskaia L, Gros V, Born E, Houssaini A, Adnot S, Boyer L
IMRB, Inserm U955, Créteil, France.
IMRB, Inserm U955, Créteil, France.
Rev Mal Respir. 2025 Mar;42(3):134-137. doi: 10.1016/j.rmr.2025.02.008. Epub 2025 Feb 28.
Vascular aging leading to microvessel depletion is a key element of organismal aging. The proposed mechanism is a deficiency of vascular endothelial growth factor (VEGF) signaling in the endothelial cells (EC), linked to the increase of a receptor in a soluble form (sVEGFR1) preventing VEGF from binding to its active receptor (VEGFR2). Without the VEGF survival signal, ECs may become senescent, contributing to aging and to various pulmonary pathologies. Deficiency of VEGF signaling in EC senescence could represent a determining element of lung aging and diseases such as pulmonary hypertension (PH) and emphysema.
导致微血管耗竭的血管老化是机体衰老的关键因素。提出的机制是内皮细胞（EC）中血管内皮生长因子（VEGF）信号传导不足，这与可溶性形式受体（sVEGFR1）增加有关，该受体可阻止VEGF与其活性受体（VEGFR2）结合。没有VEGF生存信号，内皮细胞可能会衰老，从而导致衰老和各种肺部疾病。内皮细胞衰老中VEGF信号传导不足可能是肺衰老以及诸如肺动脉高压（PH）和肺气肿等疾病的决定性因素。
