Aceves Jazmin, Mohammad Yasmeen, Arikan Pinar
Department of Medicine Warren Alpert Medical School at Brown University.
Division of Hospital Medicine Miriam Hospital.
J Brown Hosp Med. 2024 Oct 1;3(4):1-4. doi: 10.56305/001c.122624. eCollection 2024.
An 80 year old female with a past medical history of hypertension, hyperlipidemia, hypothyroidism, and chronic back pain presented to the hospital with fatigue and was found to have a severe macrocytic anemia. Blood work showed pancytopenia and positive markers of hemolysis. Additional work up was consistent with severe vitamin B12 deficiency and pernicious anemia. Her blood counts improved with blood transfusions and vitamin B12 repletion. We discuss the proposed pathophysiology of this rare case of pernicious anemia presenting with hemolysis.
一名80岁女性，既往有高血压、高脂血症、甲状腺功能减退和慢性背痛病史，因疲劳入院，被发现患有严重的大细胞性贫血。血液检查显示全血细胞减少和溶血阳性标志物。进一步检查结果与严重维生素B12缺乏和恶性贫血相符。通过输血和补充维生素B12，她的血细胞计数有所改善。我们讨论了这例罕见的伴有溶血的恶性贫血病例的推测病理生理学。
