Pandurangi Ulka, Dharani R, Dennis Joseph Leena, Priyadarshini Anuradha, Swaminathan Adikrishnan
Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus. 2025 Jan 30;17(1):e78259. doi: 10.7759/cureus.78259. eCollection 2025 Jan.
Basal cell carcinoma (BCC) is the most prevalent form of skin cancer; it is slow-growing and locally invasive with an extremely low likelihood of metastasis. The activation of the Hedgehog (HH) signaling pathway is implicated in nearly all cases, with ultraviolet radiation being the primary risk factor. While BCC typically occurs in areas of chronic sun exposure, it can rarely develop in non-sun-exposed areas, as demonstrated by our case of a 68-year-old Indian woman presenting with a BCC lesion on her left hip. Dermoscopy revealed features suggestive of basal cell carcinoma which was subsequently confirmed as adenoid type on histopathological examination. The patient underwent a successful wide excision of the lesion with clear margins, and post-operative healing was satisfactory. This case highlights the rare occurrence of BCC in non-sun-exposed areas and underscores the importance of early diagnosis and treatment. Regular follow-up is essential, as patients with a history of BCC are at high risk for subsequent skin cancers.
基底细胞癌（BCC）是最常见的皮肤癌形式；它生长缓慢且具有局部侵袭性，转移的可能性极低。几乎所有病例都与刺猬（HH）信号通路的激活有关，紫外线辐射是主要危险因素。虽然基底细胞癌通常发生在长期暴露于阳光的部位，但它很少会在非阳光暴露部位发生，我们一位68岁印度女性患者左髋部出现基底细胞癌病变的病例就证明了这一点。皮肤镜检查发现了提示基底细胞癌的特征，随后经组织病理学检查确认为腺样型。患者成功进行了病变的广泛切除，切缘清晰，术后愈合情况良好。该病例突出了基底细胞癌在非阳光暴露部位的罕见发生情况，并强调了早期诊断和治疗的重要性。定期随访至关重要，因为有基底细胞癌病史的患者后续患皮肤癌的风险很高。
