Li Pengyu, Zou Menglong, Peng Ziming
School of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.
The First Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.
Front Med (Lausanne). 2025 Feb 14;12:1508439. doi: 10.3389/fmed.2025.1508439. eCollection 2025.
The aim of this study was to assess the relationship between serum 25-hydroxyvitamin levels and all-cause mortality in patients with chronic diarrhea.
We carried out a cross-sectional study using information drawn from the National Health and Nutrition Examination Survey (NHANES). To assess mortality outcomes, we compared our data with records from the National Death Index as of December 31, 2011. The NHANES data were used to determine mortality outcome. We used a Cox regression model-based approach to analyze the relationship between serum 25-hydroxyvitamin concentrations and mortality in chronic diarrhea patients.
A total of 2,972 participants with chronic diarrhea were included in our study, 488 cases of all-cause mortality were recorded. The study showed an L-shaped relationship between 25-hydroxyvitamin concentrations and all-cause mortality with a threshold of 73.40 nmol/L. On the left side of the threshold, each 1-unit increase in 25-hydroxyvitamin concentrations was associated with a 2.2% reduction in the risk of all-cause mortality (HR 0.978; 95% CI: 0.969, 0.987); however, on the right side of the threshold, there was no significant correlation between 25(OH)D concentrations and all-cause mortality.
Serum 25-hydroxyvitamin D levels showed an L-shaped association with all-cause mortality in patients with chronic diarrhea, with 73.40 nmol/L as the potential threshold. However, because this was a cross-sectional study, only an association, not a causal relationship, can be inferred. Further prospective studies are needed to confirm these findings and explore the potential impact of vitamin D supplementation on mortality outcomes.
本研究旨在评估慢性腹泻患者血清25-羟基维生素水平与全因死亡率之间的关系。
我们利用从美国国家健康与营养检查调查（NHANES）中获取的信息进行了一项横断面研究。为了评估死亡率结果，我们将我们的数据与截至2011年12月31日的国家死亡指数记录进行了比较。NHANES数据用于确定死亡率结果。我们采用基于Cox回归模型的方法来分析慢性腹泻患者血清25-羟基维生素浓度与死亡率之间的关系。
我们的研究共纳入了2972名慢性腹泻参与者，记录了488例全因死亡病例。研究显示25-羟基维生素浓度与全因死亡率之间呈L形关系，阈值为73.40 nmol/L。在阈值左侧，25-羟基维生素浓度每增加1个单位，全因死亡风险降低2.2%（风险比0.978；95%置信区间：0.969，0.987）；然而，在阈值右侧，25(OH)D浓度与全因死亡率之间无显著相关性。
血清25-羟基维生素D水平与慢性腹泻患者的全因死亡率呈L形关联，潜在阈值为73.40 nmol/L。然而，由于这是一项横断面研究，只能推断出关联，而非因果关系。需要进一步的前瞻性研究来证实这些发现，并探索补充维生素D对死亡率结果的潜在影响。
