Wang Qing, Liu Tian, Jia Changxin, Wang Ping, Wang Yangang, He Qing
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
PeerJ. 2025 Feb 26;13:e19045. doi: 10.7717/peerj.19045. eCollection 2025.
Previous research has shown a correlation between high visceral fat levels and hyperuricemia incidence. The Chinese Visceral Adiposity Index (CVAI) assessed visceral fat status in the Chinese population. Our study investigates the correlation between CVAI and asymptomatic hyperuricemia in type 2 diabetes patients.
This cross-sectional study analyzed 1,588 hospitalized type 2 diabetes patients to investigate the association between CVAI and hyperuricemia. CVAI was included in the logistic regression analysis as both a continuous and categorical variable, and restricted cubic splines were used to assess the dose-response relationship. Additionally, subgroup analyses were performed to investigate potential interactions among variables. The predictive capability of CVAI was assessed using the receiver operating characteristic (ROC) curve based on the basic model.
The CVAI quartile group analysis revealed a higher prevalence of hyperuricemia with increasing CVAI levels. CVAI is significantly associated with hyperuricemia, as identified through multifactorial logistic regression analysis. After adjusting for all covariates, the odds ratios for CVAI in the second, third, and fourth quartiles were significantly higher than in the lowest quartile, with values of 2.688 (95% CI [1.301-5.554], = 0.008), 2.752 (95% CI [1.320-5.739], = 0.007), and 4.990 (95% CI [2.392-10.409], < 0.001), respectively. No significant interactions were observed in the subgroup analysis. Incorporating CVAI into the basic model increased the ROC curve's area under the curve to 0.714.
This study found a positive correlation between CVAI and hyperuricemia incidence in type 2 diabetes patients. Consequently, CVAI may reliably indicate hyperuricemia in this patient population.
先前的研究表明，高内脏脂肪水平与高尿酸血症发病率之间存在相关性。中国内脏脂肪指数（CVAI）用于评估中国人群的内脏脂肪状况。我们的研究调查了2型糖尿病患者中CVAI与无症状高尿酸血症之间的相关性。
这项横断面研究分析了1588例住院的2型糖尿病患者，以研究CVAI与高尿酸血症之间的关联。CVAI作为连续变量和分类变量纳入逻辑回归分析，并使用受限立方样条来评估剂量反应关系。此外，进行亚组分析以研究变量之间的潜在相互作用。基于基本模型，使用受试者工作特征（ROC）曲线评估CVAI的预测能力。
CVAI四分位数组分析显示，随着CVAI水平的升高，高尿酸血症的患病率更高。通过多因素逻辑回归分析确定，CVAI与高尿酸血症显著相关。在调整所有协变量后，第二、第三和第四四分位数中CVAI的比值比显著高于最低四分位数，分别为2.688（95%CI[1.301-5.554]，P=0.008）、2.752（95%CI[1.320-5.739]，P=0.007）和4.990（95%CI[2.392-10.409]，P<0.001）。亚组分析未观察到显著的相互作用。将CVAI纳入基本模型可使ROC曲线下面积增加至0.714。
本研究发现2型糖尿病患者中CVAI与高尿酸血症发病率呈正相关。因此，CVAI可能可靠地指示该患者群体中的高尿酸血症。
