Li Yanlong, Li Baoyu, Gou Yuqin, Tian Xudong, Chang Lijun, Qu Chaoxu
Diagnosis and Treatment Center for Spleen and Stomach Diseases, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730030, Gansu, China.
College of Integrated Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China.
Open Med (Wars). 2025 Feb 25;20(1):20241126. doi: 10.1515/med-2024-1126. eCollection 2025.
The purpose of this article was to unravel the clinical efficacy of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in the treatment of mild-to-moderate ulcerative colitis (UC).
Eighty-six mild-to-moderate UC patients were selected as study subjects and randomized into the control group (treated with mesalazine enteric-coated tablets [Salofalk]) and the observation group (treated with mesalazine enteric-coated tablets, Bifidobacterium Tetravaccine Tablets, and Yiyi Baitouweng Decoction retention enema). The clinical efficacy, colonoscopy score, serum levels of inflammatory factors, and the incidence of adverse reactions were compared.
The clinical efficacy of patients in the observation group was better in contrast to the control group. After 8 weeks of treatment, the colonoscopy score, and levels of TNF-α, IFN-γ, CRP, and ESR were lower, while IL-10 levels were higher in patients of both groups than those before treatment; lower colonoscopy score and levels of TNF-α, IFN-γ, CRP, and ESR and higher IL-10 levels were observed in the observation group versus the control group.
Probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema have remarkable clinical effects in treating mild-to-moderate UC.
本文旨在探讨益生菌联合美沙拉嗪及乙乙白头翁汤保留灌肠治疗轻至中度溃疡性结肠炎（UC）的临床疗效。
选取86例轻至中度UC患者作为研究对象，随机分为对照组（采用美沙拉嗪肠溶片[莎尔福]治疗）和观察组（采用美沙拉嗪肠溶片、双歧杆菌四联活菌片及乙乙白头翁汤保留灌肠治疗）。比较两组的临床疗效、结肠镜评分、血清炎症因子水平及不良反应发生率。
观察组患者的临床疗效优于对照组。治疗8周后，两组患者的结肠镜评分、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、C反应蛋白（CRP）及血沉（ESR）水平均低于治疗前，白细胞介素-10（IL-10）水平均高于治疗前；与对照组相比，观察组患者的结肠镜评分、TNF-α、IFN-γ、CRP及ESR水平更低，IL-10水平更高。
益生菌联合美沙拉嗪及乙乙白头翁汤保留灌肠治疗轻至中度UC具有显著临床效果。
