Petrželová Kamila, Bárta Ondřej, Héžová Renata, Andrýsková Alžběta, Hošek Jan, Štarha Pavel
Department of Inorganic Chemistry, Palacký University Olomouc, 17. listopadu 1192/12, 77146, Olomouc, Czech Republic.
Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100, Brno, Czech Republic.
ChemistryOpen. 2025 Sep;14(9):e202500026. doi: 10.1002/open.202500026. Epub 2025 Mar 3.
The long-known dinuclear complexes of the general formula [M(μ-X)(η-Cp*)X] (1-4; M=Rh or Ir, X=Br or I; HCp*=pentamethylcyclopentadiene) represent important intermediates for the preparation of biologically (e. g., anticancer or antimicrobial) and catalytically active half-sandwich rhodium(III) and iridium(III) complexes. Here we report the optimized rapid microwave-assisted syntheses of the mentioned dinuclear synthons 1-4. With respect to their following synthetic utilization, we examined their antiproliferative activity in the representative human cancer cell lines, where they did not show any relevant cytotoxicity. However, the iridium complexes 3 and 4 exhibited considerable catalytic activity in a model transfer hydrogenation of acetophenone using propan-2-ol as the hydrogen source. The obtained comprehensive data sets can be useful in the evaluation of the ligand effects in complexes prepared from 1-4 and used in e. g. bioinorganic and catalytic applications.
通式为[M(μ-X)(η-Cp*)X]（1-4；M = Rh或Ir，X = Br或I；HCp* = 五甲基环戊二烯）的双核配合物早已为人所知，它们是制备具有生物活性（例如抗癌或抗菌）和催化活性的半夹心铑(III)和铱(III)配合物的重要中间体。在此，我们报告了上述双核合成子1-4的优化快速微波辅助合成方法。考虑到它们后续的合成应用，我们检测了它们在代表性人类癌细胞系中的抗增殖活性，结果表明它们没有表现出任何相关的细胞毒性。然而，铱配合物3和4在以2-丙醇为氢源的苯乙酮模型转移氢化反应中表现出相当大的催化活性。所获得的全面数据集可用于评估由1-4制备并用于例如生物无机和催化应用的配合物中的配体效应。
