Liu Mei-Juan, Zhang Yun, Zhu Ke, Li Wen-Wen, Liu Chen, Jiang Shu, Shang Er-Xin, Duan Jin-Ao
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing210023, China.
J Asian Nat Prod Res. 2025 Sep;27(9):1332-1346. doi: 10.1080/10286020.2025.2459603. Epub 2025 Mar 3.
This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.
本研究旨在从肠道屏障功能的角度探讨泻心汤改善2型糖尿病的潜在机制。结果表明，泻心汤可显著促进结肠上皮细胞中GPRs的表达，同时抑制HDACs的表达，进而显著提高TGF-β1和IL-18水平，调节T细胞分化，进一步维持肠道免疫稳态。同时，它可显著抑制炎症信号通路，改善肠道屏障功能，缓解2型糖尿病。
